Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/11998
ชื่อเรื่อง: Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37
ผู้แต่ง: Noppawan S.
Mongkolthanaruk W.
Suwannasai N.
Senawong T.
Moontragoon P.
Boonmak J.
Youngme S.
McCloskey S.
Keywords: cytochalasin
fungal extract
pentaminolarin
pentapeptide
xylochalasin
antineoplastic agent
cyclopeptide
cytochalasin
controlled study
cytotoxicity
density functional theory
drug purification
drug structure
HCT 116 cell line
HeLa cell line
HT-29 cell line
human
human cell
IC50
MTT assay
nonhuman
Thailand
Vero cell line
Xylariales
chemistry
conformation
drug screening
isolation and purification
pathogenicity
tumor cell line
Antineoplastic Agents
Cell Line, Tumor
Cytochalasins
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Peptides, Cyclic
Xylariales
วันที่เผยแพร่: 2020
บทคัดย่อ: A new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC50 = 19.60 µg/mL), HT29 (IC50 = 17.31 µg/mL), HCT116 (IC50 = 14.28 µg/mL), MCF-7 (IC50 = 15.38 µg/mL), and Vero (IC50 = 24.97 µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
URI: https://ir.swu.ac.th/jspui/handle/123456789/11998
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053874640&doi=10.1080%2f14786419.2018.1488709&partnerID=40&md5=09eec464f381ef64953383ac92d1500f
ISSN: 14786419
Appears in Collections:Scopus 1983-2021

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