Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/11935
ชื่อเรื่อง: Formulation of monomyristin-loaded polyester nanoparticles with controlled surface properties
ผู้แต่ง: Boondireke S.
Liu C.
T. Wongsatayanon B.
Léonard M.
Durand A.
Keywords: Agglomeration
Biochemistry
Dextran
Encapsulation
Ionic strength
Lactic acid
Mammals
Nanoparticles
Proteins
Sols
Bovine serum albumins
Functionalized dextrans
Hydrophobically modified dextran
Monomyristin
Poly lactic acid
Polyester nanoparticles
Structural characteristics
Transferrin
Suspensions (fluids)
bovine serum albumin
dextran
monoacylglycerol
monomyristin
nanoparticle
polyester
polylactic acid
stabilizing agent
transferrin
unclassified drug
Article
colloid
controlled study
covalent bond
drug formulation
drug solubility
freeze drying
ionic strength
nanoencapsulation
priority journal
surface property
suspension
วันที่เผยแพร่: 2020
บทคัดย่อ: Monomyristin (MM), a monoacylglycerol with very low water solubility, has been reported to exhibit anti-proliferative property against cervical cancer cells. In order to increase its bioavailability, MM was encapsulated for the first time inside dextran-covered poly(lactic acid) nanoparticles. The use of dextran-based stabilizers with convenient structural characteristics was shown to provide important end-use properties to particle suspensions like colloidal stability during extensive washing steps or in the presence of high ionic strengths, easy reconstitution after lyophilization without particle aggregation in the absence of added cryoprotectant. Furthermore, immobilization of proteins at the surface of loaded particles was investigated with Bovine Serum Albumin and Transferrin using functionalized dextran-based stabilizers. The nature of links (covalent or non-covalent) between proteins and dextran-based superficial layer was discussed. © 2020 Elsevier B.V.
URI: https://ir.swu.ac.th/jspui/handle/123456789/11935
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080057111&doi=10.1016%2fj.colsurfa.2020.124616&partnerID=40&md5=66d7ebeb34d1fc9abdbdc83d70f21028
ISSN: 9277757
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.