dc.contributor.author |
Suksamrarn S. |
|
dc.contributor.author |
Komutiban O. |
|
dc.contributor.author |
Ratananukul P. |
|
dc.contributor.author |
Chimnoi N. |
|
dc.contributor.author |
Lartpornmatulee N. |
|
dc.contributor.author |
Suksamrarn A. |
|
dc.date.accessioned |
2021-04-05T04:32:23Z |
|
dc.date.available |
2021-04-05T04:32:23Z |
|
dc.date.issued |
2006 |
|
dc.identifier.issn |
92363 |
|
dc.identifier.other |
2-s2.0-33645225308 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/15038 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645225308&doi=10.1248%2fcpb.54.301&partnerID=40&md5=1b715d7fd1657772b8ec277a8814a08d |
|
dc.description.abstract |
Three new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC50 values of 2.8, 3.53, and 3.72 μg/ml, respectively. Among the isolates, α-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC50 value of 0.92 μg/ml, an activity greater than that of the standard drug ellipticine (IC 50=1.46 mg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 μg/ml and 1.08 μg/ml. © 2006 Pharmaceutical Society of Japan. |
|
dc.subject |
11 hydroxy 1 isomangostin |
|
dc.subject |
8 desoxygartanin |
|
dc.subject |
alpha mangostin |
|
dc.subject |
antineoplastic agent |
|
dc.subject |
demethylcalabaxanthone |
|
dc.subject |
gamma mangostin |
|
dc.subject |
garcinone b |
|
dc.subject |
garcinone c |
|
dc.subject |
garcinone d |
|
dc.subject |
garcinone e |
|
dc.subject |
gartanin |
|
dc.subject |
mangostanin |
|
dc.subject |
mangostanol |
|
dc.subject |
mangostenones c |
|
dc.subject |
mangostenones d |
|
dc.subject |
mangostenones e |
|
dc.subject |
mangostin |
|
dc.subject |
mangostinone |
|
dc.subject |
thwaitesixanthone |
|
dc.subject |
unclassified drug |
|
dc.subject |
xanthone derivative |
|
dc.subject |
article |
|
dc.subject |
breast cancer |
|
dc.subject |
cancer cell culture |
|
dc.subject |
controlled study |
|
dc.subject |
cytotoxicity |
|
dc.subject |
drug effect |
|
dc.subject |
drug isolation |
|
dc.subject |
drug structure |
|
dc.subject |
fruit |
|
dc.subject |
Garcinia mangostana |
|
dc.subject |
human |
|
dc.subject |
human cell |
|
dc.subject |
IC 50 |
|
dc.subject |
lung small cell cancer |
|
dc.subject |
mass spectrometry |
|
dc.subject |
nonhuman |
|
dc.subject |
nuclear magnetic resonance |
|
dc.subject |
squamous cell carcinoma |
|
dc.subject |
Antineoplastic Agents, Phytogenic |
|
dc.subject |
Carbohydrate Conformation |
|
dc.subject |
Cell Line, Tumor |
|
dc.subject |
Drug Screening Assays, Antitumor |
|
dc.subject |
Fruit |
|
dc.subject |
Garcinia |
|
dc.subject |
Humans |
|
dc.subject |
Magnetic Resonance Spectroscopy |
|
dc.subject |
Spectrometry, Mass, Fast Atom Bombardment |
|
dc.subject |
Spectrophotometry, Infrared |
|
dc.subject |
Spectrophotometry, Ultraviolet |
|
dc.subject |
Xanthines |
|
dc.title |
Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Chemical and Pharmaceutical Bulletin. Vol 54, No.3 (2006), p.301-305 |
|
dc.identifier.doi |
10.1248/cpb.54.301 |
|