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Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells

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dc.contributor.author Wattanapitayakul S.K.
dc.contributor.author Suwatronnakorn M.
dc.contributor.author Chularojmontri L.
dc.contributor.author Herunsalee A.
dc.contributor.author Niumsakul S.
dc.contributor.author Charuchongkolwongse S.
dc.contributor.author Chansuvanich N.
dc.date.accessioned 2021-04-05T04:32:11Z
dc.date.available 2021-04-05T04:32:11Z
dc.date.issued 2007
dc.identifier.issn 3788741
dc.identifier.other 2-s2.0-33947122236
dc.identifier.uri https://ir.swu.ac.th/jspui/handle/123456789/14950
dc.identifier.uri https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947122236&doi=10.1016%2fj.jep.2006.09.037&partnerID=40&md5=4b8589f68d1c72d28db3f942fc5e21a8
dc.description.abstract The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. This study investigated effect of KP on endothelial function. Studies in human umbilical vein endothelial cells (HUVEC) showed that KP dose-dependently increased nitrite concentrations in culture media after 48 h incubation. eNOS mRNA and protein expression were also enhanced. The induction of eNOS mRNA was detected at 4 h and plateau at 48 h while iNOS expression was not observed. These data demonstrate that KP has a great potential for a supplemental use in vascular endothelial health promotion. © 2006 Elsevier Ireland Ltd. All rights reserved.
dc.subject alcohol
dc.subject endothelial nitric oxide synthase
dc.subject Kaempferia parviflora extract
dc.subject messenger RNA
dc.subject nitric oxide
dc.subject nitrite
dc.subject plant extract
dc.subject unclassified drug
dc.subject article
dc.subject concentration response
dc.subject controlled study
dc.subject endothelium cell
dc.subject gastrointestinal disease
dc.subject gene expression
dc.subject gene induction
dc.subject health promotion
dc.subject human
dc.subject human cell
dc.subject Kaempferia parviflora
dc.subject medicinal plant
dc.subject nonhuman
dc.subject nucleotide sequence
dc.subject protein expression
dc.subject rhizome
dc.subject stomach ulcer
dc.subject traditional medicine
dc.subject vascular endothelium
dc.subject Zingiberaceae
dc.subject Dose-Response Relationship, Drug
dc.subject Endothelial Cells
dc.subject Gene Expression Regulation
dc.subject Humans
dc.subject Medicine, Oriental Traditional
dc.subject Nitric Oxide
dc.subject Nitric Oxide Synthase Type II
dc.subject Nitric Oxide Synthase Type III
dc.subject Nitrites
dc.subject Phytotherapy
dc.subject Plant Extracts
dc.subject Plants, Medicinal
dc.subject Rhizome
dc.subject RNA, Messenger
dc.subject Thailand
dc.subject Umbilical Veins
dc.subject Zingiberaceae
dc.subject Kaempferia parviflora
dc.subject Zingiberaceae
dc.title Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells
dc.type Article
dc.rights.holder Scopus
dc.identifier.bibliograpycitation Journal of Ethnopharmacology. Vol 110, No.3 (2007), p.559-562
dc.identifier.doi 10.1016/j.jep.2006.09.037


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