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Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: A case report and literature review

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dc.contributor.author Prayongratana K.
dc.contributor.author Kulpraneet M.
dc.contributor.author Panichchob P.
dc.contributor.author Tantisiriwat W.
dc.date.accessioned 2021-04-05T04:32:00Z
dc.date.available 2021-04-05T04:32:00Z
dc.date.issued 2008
dc.identifier.issn 1252208
dc.identifier.other 2-s2.0-44249109745
dc.identifier.uri https://ir.swu.ac.th/jspui/handle/123456789/14868
dc.identifier.uri https://www.scopus.com/inward/record.uri?eid=2-s2.0-44249109745&partnerID=40&md5=d3f9b5a03a06bbf351bb875cceb8ca3a
dc.description.abstract A forty-three-year-old Thai man presented with acute fever and dyspnea for one week with bilateral patchy infiltration, pancytopenia with monoblast. Bone marrow study was consistent with acute monoblastic leukemia. Lung lesions rapidly progressed to acute respiratory failure, which required intubation. Bronchoscopy with bronchoalveolar lavage revealed monotonous monoblast infiltration. Induction chemotherapy with 7 + 3 regimen was administered to halt the progression of leukemic pulmonary infiltration. Although there was clinical improvement, the chest radiograph developed crescent formation in the right upper lung field. Invasive pulmonary aspergillosis was suspected and successfully treated with antifungal agent. After peripheral blood recovery, bone marrow evaluation was performed and complete remission was established. HLA matching was sent to prepare for hematopoietic stem cell transplantation (HSCT). The literature review showed that the appropriate treatment for the patients with t(10;11)(p12;q23) was HSCT, but there was no data concerning correlation of t(10;11)(p12;q23) and pulmonary infiltration. This may be due to the low incidence of leukemic infiltration of acute leukemia patients, which is 0.48% and 3.06% in acute myeloid leukemia and acute monoblastic leukemia, respectively.
dc.subject caspofungin
dc.subject cytarabine
dc.subject idarubicin
dc.subject voriconazole
dc.subject acute disease
dc.subject acute granulocytic leukemia
dc.subject acute lymphoblastic leukemia
dc.subject acute monocytic leukemia
dc.subject acute respiratory failure
dc.subject adult
dc.subject article
dc.subject bleeding
dc.subject bone marrow examination
dc.subject bronchoscopy
dc.subject cancer chemotherapy
dc.subject cancer regression
dc.subject case report
dc.subject cell infiltration
dc.subject continuous infusion
dc.subject cytogenetics
dc.subject disease course
dc.subject dyspnea
dc.subject fever
dc.subject hematopoietic stem cell transplantation
dc.subject human
dc.subject incidence
dc.subject intubation
dc.subject laboratory test
dc.subject lung aspergillosis
dc.subject lung infiltrate
dc.subject lung lavage
dc.subject lung lesion
dc.subject male
dc.subject pancytopenia
dc.subject thorax radiography
dc.subject treatment outcome
dc.subject Adult
dc.subject Antibiotics, Antineoplastic
dc.subject Antifungal Agents
dc.subject Antimetabolites, Antineoplastic
dc.subject Aspergillosis, Allergic Bronchopulmonary
dc.subject Bronchoalveolar Lavage
dc.subject Cytarabine
dc.subject Echinocandins
dc.subject Hematopoietic Stem Cell Transplantation
dc.subject Humans
dc.subject Idarubicin
dc.subject Leukemia, Monocytic, Acute
dc.subject Lung Neoplasms
dc.subject Male
dc.subject Pyrimidines
dc.subject Thailand
dc.subject Triazoles
dc.title Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: A case report and literature review
dc.type Article
dc.rights.holder Scopus
dc.identifier.bibliograpycitation Journal of the Medical Association of Thailand. Vol 91, No.4 (2008), p.559-563


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