dc.contributor.author |
Weecharangsan W. |
|
dc.contributor.author |
Yu B. |
|
dc.contributor.author |
Liu S. |
|
dc.contributor.author |
Pang J.X. |
|
dc.contributor.author |
Lee L.J. |
|
dc.contributor.author |
Marcucci G. |
|
dc.contributor.author |
Lee R.J. |
|
dc.date.accessioned |
2021-04-05T03:37:05Z |
|
dc.date.available |
2021-04-05T03:37:05Z |
|
dc.date.issued |
2010 |
|
dc.identifier.issn |
2507005 |
|
dc.identifier.other |
2-s2.0-77649246832 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/14762 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77649246832&partnerID=40&md5=58a80b4e5e45b2b1ee0f7b97fed14f3f |
|
dc.description.abstract |
Background: Disulfide-linked oligodeoxyribonucleotide (ODN) liposomes were formulated and evaluated for the delivery of antisense ODN G3139 in KB human oral carcinoma cells. Materials and Methods: Liposomes composed of 1,2-di-(9Z-octadecenoyl)-3-trimethylammo-nium-propane(DOTAP)/egg phosphatidylcholine/α-tocopheryl polyethylene glycol 1000 succinate were incorporated with hydrophobized disulfide-linked ODN. Disulfide-linked ODN liposomes were characterized for their size, ODN intracellular delivery, Bcl-2 mRNA and protein expression, growth inhibition, and chemosensitization. Results: Intracellular delivery of ODN with disulfide-linked ODN liposomes was more efficient than that with non-liposomal hydrophobized disulfide-linked ODN. Treatment of the cells with disulfide-linked ODN liposomes resulted in efficient Bcl-2 down-regulation greater than that with hydrophobized disulfide-linked ODN and consistent with that of cellular growth inhibition and the sensitization to daunorubicin in KB cells. Disulfide-linked ODN liposomes exhibited superior colloidal stability during 5-week storage. Conclusion: Disulfide-linked liposomes are effective delivery vehicles for antisense ODN. |
|
dc.subject |
1,2 dioleoyl 3 trimethylammoniopropane |
|
dc.subject |
daunorubicin |
|
dc.subject |
disulfide linked liposome |
|
dc.subject |
liposome |
|
dc.subject |
macrogol derivative |
|
dc.subject |
messenger RNA |
|
dc.subject |
oblimersen |
|
dc.subject |
phosphatidylcholine |
|
dc.subject |
polyethylene glycol 1000 succinate |
|
dc.subject |
protein bcl 2 |
|
dc.subject |
unclassified drug |
|
dc.subject |
article |
|
dc.subject |
cell growth |
|
dc.subject |
cell strain KB |
|
dc.subject |
chemosensitization |
|
dc.subject |
controlled study |
|
dc.subject |
down regulation |
|
dc.subject |
growth inhibition |
|
dc.subject |
human |
|
dc.subject |
human cell |
|
dc.subject |
intracellular transport |
|
dc.subject |
mouth carcinoma |
|
dc.subject |
nonviral gene delivery system |
|
dc.subject |
priority journal |
|
dc.subject |
protein expression |
|
dc.subject |
Antibiotics, Antineoplastic |
|
dc.subject |
Cell Growth Processes |
|
dc.subject |
Colloids |
|
dc.subject |
Daunorubicin |
|
dc.subject |
Disulfides |
|
dc.subject |
Down-Regulation |
|
dc.subject |
Drug Stability |
|
dc.subject |
Genes, bcl-2 |
|
dc.subject |
Humans |
|
dc.subject |
KB Cells |
|
dc.subject |
Liposomes |
|
dc.subject |
Oligodeoxyribonucleotides, Antisense |
|
dc.subject |
Transfection |
|
dc.title |
Disulfide-linked liposomes: Effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139 |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Anticancer Research. Vol 30, No.1 (2010), p.31-38 |
|