dc.contributor.author |
Pingaew R. |
|
dc.contributor.author |
Prachayasittikul S. |
|
dc.contributor.author |
Ruchirawat S. |
|
dc.date.accessioned |
2021-04-05T03:36:48Z |
|
dc.date.available |
2021-04-05T03:36:48Z |
|
dc.date.issued |
2010 |
|
dc.identifier.issn |
14203049 |
|
dc.identifier.other |
2-s2.0-77649206777 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/14728 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77649206777&doi=10.3390%2fmolecules15020988&partnerID=40&md5=759ed2e7755d636fef97c83c395b6aa5 |
|
dc.description.abstract |
Thiosemicarbazone analogs of papaveraldine and related compounds 1-6 were synthesized and evaluated for cytotoxic and antimalarial activities. The cytotoxic activity was tested against HuCCA-1, HepG2, A549 and MOLT-3 human cancer cell lines. Thiosemicarbazones 1-5 displayed cytotoxicity toward all the tested cell lines, while compounds 2-5 selectively showed potent activity against the MOLT-3 cell lines. Significantly, N(4)-phenyl-2-benzoylpyridine thiosemicarbazone 4 exhibited the most potent activity against HuCCA-1, HepG2, A549 and MOLT-3 cell lines with IC50 values of 0.03, 4.75, 0.04 and 0.004 μg/mL, respectively. In addition, 2-benzoylpyridine thiosemicarbazones 3 and 4 showed antimalarial activity against Plasmodium falciparum with IC 50 of 10-7 to < 10-6 M. The study demonstrates the quite promising activity of analog 4 as a lead molecule for further development. © 2010 by the authors. |
|
dc.subject |
antimalarial agent |
|
dc.subject |
antineoplastic agent |
|
dc.subject |
isoquinoline derivative |
|
dc.subject |
thiosemicarbazone derivative |
|
dc.subject |
article |
|
dc.subject |
cell death |
|
dc.subject |
chemistry |
|
dc.subject |
drug effect |
|
dc.subject |
human |
|
dc.subject |
Plasmodium falciparum |
|
dc.subject |
synthesis |
|
dc.subject |
tumor cell line |
|
dc.subject |
Antimalarials |
|
dc.subject |
Antineoplastic Agents |
|
dc.subject |
Cell Death |
|
dc.subject |
Cell Line, Tumor |
|
dc.subject |
Humans |
|
dc.subject |
Isoquinolines |
|
dc.subject |
Plasmodium falciparum |
|
dc.subject |
Thiosemicarbazones |
|
dc.title |
Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Molecules. Vol 15, No.2 (2010), p.988-996 |
|
dc.identifier.doi |
10.3390/molecules15020988 |
|