dc.contributor.author |
Sudta P. |
|
dc.contributor.author |
Jiarawapi P. |
|
dc.contributor.author |
Suksamrarn A. |
|
dc.contributor.author |
Hongmanee P. |
|
dc.contributor.author |
Suksamrarn S. |
|
dc.date.accessioned |
2021-04-05T03:33:11Z |
|
dc.date.available |
2021-04-05T03:33:11Z |
|
dc.date.issued |
2013 |
|
dc.identifier.issn |
92363 |
|
dc.identifier.other |
2-s2.0-84873593744 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/14103 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873593744&doi=10.1248%2fcpb.c12-00874&partnerID=40&md5=7044536b1db8ec73e49d221fe3bc1dfb |
|
dc.description.abstract |
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL. © 2013 The Pharmaceutical Society of Japan. |
|
dc.subject |
3,6 di o (4 bromobutyl)tetrahydro alpha mangostin |
|
dc.subject |
3,6 di o allyltetrahydro alpha mangostin |
|
dc.subject |
3,6 di o benzyltetrahydro alpha mangostin |
|
dc.subject |
3,6 di o ethyl alpha mangostin |
|
dc.subject |
3,6 di o methyl alpha mangostin |
|
dc.subject |
6 methoxytetrahydro alpha mangostin |
|
dc.subject |
6 o (4 bromobutyl)tetrahydro alpha mangostin |
|
dc.subject |
6 o allyltetrahydro alpha mangostin |
|
dc.subject |
6 o benzyltetrahydro alpha mangostin |
|
dc.subject |
6 o butyltetrahydro alpha mangostin |
|
dc.subject |
6 o ethyl alpha mangostin |
|
dc.subject |
6 o methyl alpha mangostin |
|
dc.subject |
6 o methyltetrahydro alpha mangostin |
|
dc.subject |
6 o methyltetrahydro alpha mangostin 3 o acetate |
|
dc.subject |
6 o pentyltetrahydro alpha mangostin |
|
dc.subject |
alpha mangostin 3,6 di o acetate |
|
dc.subject |
alpha mangostin 3,6 di o benzoate |
|
dc.subject |
alpha mangostin 6 o acetate |
|
dc.subject |
alpha mangostin 6 o benzoate |
|
dc.subject |
alpha mangostin derivative |
|
dc.subject |
antimycobacterial agent |
|
dc.subject |
tetrahydro alpha mangostin |
|
dc.subject |
tetrahydro alpha mangostin 3,6 di o acetate |
|
dc.subject |
tetrahydro alpha mangostin 3,6 di o benzoate |
|
dc.subject |
tetrahydro alpha mangostin 3,6 di o butyrate |
|
dc.subject |
tetrahydro alpha mangostin 3,6 di o propionate |
|
dc.subject |
tetrahydro alpha mangostin 6 o acetate |
|
dc.subject |
tetrahydro alpha mangostin 6 o benzoate |
|
dc.subject |
tuberculostatic agent |
|
dc.subject |
unclassified drug |
|
dc.subject |
unindexed drug |
|
dc.subject |
acylation |
|
dc.subject |
alkylation |
|
dc.subject |
antibacterial activity |
|
dc.subject |
article |
|
dc.subject |
drug activity |
|
dc.subject |
drug structure |
|
dc.subject |
drug synthesis |
|
dc.subject |
minimum inhibitory concentration |
|
dc.subject |
multidrug resistance |
|
dc.subject |
Mycobacterium tuberculosis |
|
dc.subject |
nonhuman |
|
dc.subject |
Anti-Bacterial Agents |
|
dc.subject |
Drug Resistance, Multiple, Bacterial |
|
dc.subject |
Microbial Sensitivity Tests |
|
dc.subject |
Mycobacterium tuberculosis |
|
dc.subject |
Xanthones |
|
dc.title |
Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Chemical and Pharmaceutical Bulletin. Vol 61, No.2 (2013), p.194-203 |
|
dc.identifier.doi |
10.1248/cpb.c12-00874 |
|