| dc.contributor.author |
Pingaew R. |
|
| dc.contributor.author |
Worachartcheewan A. |
|
| dc.contributor.author |
Prachayasittikul V. |
|
| dc.contributor.author |
Prachayasittikul S. |
|
| dc.contributor.author |
Ruchirawat S. |
|
| dc.contributor.author |
Prachayasittikul V. |
|
| dc.date.accessioned |
2021-04-05T03:32:46Z |
|
| dc.date.available |
2021-04-05T03:32:46Z |
|
| dc.date.issued |
2013 |
|
| dc.identifier.issn |
15701808 |
|
| dc.identifier.other |
2-s2.0-84887864374 |
|
| dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/13968 |
|
| dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887864374&doi=10.2174%2f15701808113109990004&partnerID=40&md5=a3eee064f49f651dd797425acaef207d |
|
| dc.description.abstract |
Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers. |
|
| dc.subject |
8 aminoquinoline derivative |
|
| dc.subject |
copper complex |
|
| dc.subject |
doxorubicin |
|
| dc.subject |
etoposide |
|
| dc.subject |
ligand |
|
| dc.subject |
manganese derivative |
|
| dc.subject |
metal complex |
|
| dc.subject |
nickel complex |
|
| dc.subject |
reactive nitrogen species |
|
| dc.subject |
reactive oxygen metabolite |
|
| dc.subject |
superoxide |
|
| dc.subject |
superoxide dismutase |
|
| dc.subject |
transition element |
|
| dc.subject |
uracil derivative |
|
| dc.subject |
antioxidant activity |
|
| dc.subject |
article |
|
| dc.subject |
cancer cell culture |
|
| dc.subject |
complex formation |
|
| dc.subject |
controlled study |
|
| dc.subject |
drug cytotoxicity |
|
| dc.subject |
drug synthesis |
|
| dc.subject |
human |
|
| dc.subject |
human cell |
|
| dc.subject |
IC 50 |
|
| dc.subject |
infrared spectroscopy |
|
| dc.subject |
priority journal |
|
| dc.subject |
structure activity relation |
|
| dc.subject |
X ray powder diffraction |
|
| dc.title |
Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities |
|
| dc.type |
Article |
|
| dc.rights.holder |
Scopus |
|
| dc.identifier.bibliograpycitation |
Letters in Drug Design and Discovery. Vol 10, No.9 (2013), p.859-864 |
|
| dc.identifier.doi |
10.2174/15701808113109990004 |
|