dc.contributor.author |
Benjakul R. |
|
dc.contributor.author |
Kongkaneramit L. |
|
dc.contributor.author |
Sarisuta N. |
|
dc.contributor.author |
Moongkarndi P. |
|
dc.contributor.author |
Müller-Goymann C.C. |
|
dc.date.accessioned |
2021-04-05T03:25:32Z |
|
dc.date.available |
2021-04-05T03:25:32Z |
|
dc.date.issued |
2015 |
|
dc.identifier.issn |
9594973 |
|
dc.identifier.other |
2-s2.0-84938780546 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/13674 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938780546&doi=10.1097%2fCAD.0000000000000235&partnerID=40&md5=11c202a32a47001838e75685e98bd74f |
|
dc.description.abstract |
The aims of this study were to develop α-mangostin liposomes as well as to evaluate their physicochemical properties and cytotoxic activity. α-Mangostin liposomes were prepared using the reverse-phase evaporation method with lipid composition of phosphatidylcholine to cholesterol at 7: 3 molar ratios; their physicochemical properties and antiproliferative activity were assessed using an MTT assay in four human carcinoma cells [that is, human lung epithelial carcinoma (Calu-3), human colon carcinoma (HT-29), human breast carcinoma (MCF-7), and human colon carcinoma (Caco-2) cells], and two human normal cells [that is, human dermal fibroblasts (HDF) and human adult low-calcium elevated temperature (HaCaT) keratinocytes]. Determinations of morphological changes and oligonucleosomal DNA fragments were also carried out. The liposomal dispersions obtained were unilamellar vesicles as confirmed by cryotransmission and freeze-fracture electron microscopy with a particle size of 114 nm and a ζ potential of -2.56 mV. The 31P-NMR spectra showed that α-mangostin molecules orientated in the phospholipid bilayer membrane. The α-mangostin could appreciably be entrapped with an efficiency and loading of 81 and 4%, respectively. The antiproliferative activity of α-mangostin liposomes in various cancer and normal cells showed a dose-dependent inhibition in all treated cell lines. The antiproliferative effect of α-mangostin liposomes was found to be associated with apoptosis, with differences in sensitivity among the cell lines treated. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. |
|
dc.subject |
alpha mangostin liposome |
|
dc.subject |
antineoplastic agent |
|
dc.subject |
cholesterol |
|
dc.subject |
DNA fragment |
|
dc.subject |
liposome |
|
dc.subject |
phosphatidylcholine |
|
dc.subject |
unclassified drug |
|
dc.subject |
antineoplastic agent |
|
dc.subject |
liposome |
|
dc.subject |
mangostin |
|
dc.subject |
xanthone derivative |
|
dc.subject |
adult |
|
dc.subject |
antiproliferative activity |
|
dc.subject |
apoptosis |
|
dc.subject |
Article |
|
dc.subject |
breast carcinoma |
|
dc.subject |
carcinoma cell |
|
dc.subject |
cell death |
|
dc.subject |
cell structure |
|
dc.subject |
colon carcinoma |
|
dc.subject |
controlled study |
|
dc.subject |
dispersion |
|
dc.subject |
drug cytotoxicity |
|
dc.subject |
drug mechanism |
|
dc.subject |
electron microscopy |
|
dc.subject |
fibroblast |
|
dc.subject |
human |
|
dc.subject |
human cell |
|
dc.subject |
human tissue |
|
dc.subject |
keratinocyte |
|
dc.subject |
lipid composition |
|
dc.subject |
lung carcinoma |
|
dc.subject |
MTT assay |
|
dc.subject |
particle size |
|
dc.subject |
phospholipid bilayer |
|
dc.subject |
phosphorus nuclear magnetic resonance |
|
dc.subject |
physical chemistry |
|
dc.subject |
priority journal |
|
dc.subject |
cell death |
|
dc.subject |
cell line |
|
dc.subject |
cell proliferation |
|
dc.subject |
chemistry |
|
dc.subject |
drug effects |
|
dc.subject |
nuclear magnetic resonance spectroscopy |
|
dc.subject |
tumor cell line |
|
dc.subject |
Antineoplastic Agents |
|
dc.subject |
Cell Death |
|
dc.subject |
Cell Line |
|
dc.subject |
Cell Line, Tumor |
|
dc.subject |
Cell Proliferation |
|
dc.subject |
Humans |
|
dc.subject |
Liposomes |
|
dc.subject |
Magnetic Resonance Spectroscopy |
|
dc.subject |
Xanthones |
|
dc.title |
Cytotoxic effect and mechanism inducing cell death of α-mangostin liposomes in various human carcinoma and normal cells |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Anti-Cancer Drugs. Vol 26, No.8 (2015), p.824-834 |
|
dc.identifier.doi |
10.1097/CAD.0000000000000235 |
|