dc.contributor.author |
Sukseree S. |
|
dc.contributor.author |
Sophonnithiprasert T. |
|
dc.contributor.author |
Pradidarcheep W. |
|
dc.contributor.author |
Nilbunga S. |
|
dc.contributor.author |
Nilwarangoon S. |
|
dc.contributor.author |
Watanapokasin R. |
|
dc.date.accessioned |
2021-04-05T03:25:17Z |
|
dc.date.available |
2021-04-05T03:25:17Z |
|
dc.date.issued |
2015 |
|
dc.identifier.issn |
1252208 |
|
dc.identifier.other |
2-s2.0-84957672524 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/13642 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957672524&partnerID=40&md5=af65bfe2cd12cffe62a520a1621bc8c7 |
|
dc.description.abstract |
To determine the effects of alpha-mangostin on thioacetamide (TAA)-induced liver cirrhosis in rats. Material and Method: Male Wistar rats were divided into 3 groups and treated with intraperitoneal injections of TAA (200 mg/kg) 3 times per week for per week for 8, 12 and 16 weeks, respectively. One subgroup was left untreated whereas the other two were treated either with 100 mg/kg α-mangostin or vehicle alone (80% DMSO, 20% water), which were administered intraperitoneally 3 times per week for a total of 4 weeks. The incidence of fibrotic nodules on the liver and the serum levels of the liver enzymes aspartate transaminase (AST) and alanine transaminase (ALT) were measured. Moreover, the liver cirrhosis-related genes expression and p53 protein level in liver were analyzed by quantitative reverse transcription PCR and Western blot analysis, respectively. Results: Fibrotic nodules on the liver were formed upon treatment with TAA for 12 or 16 weeks. The nodules were then reduced by treatment with α-mangostin as compared to treatment with the vehicle DMSO. Moreover, the serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decreased as compared to DMSO alone. The liver cirrhosisrelated genes expression showed no significant differences, whereas the p53 protein level in liver showed that α-mangostin reduced risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. Conclusion: The results suggest that α-mangostin has a beneficial therapeutic effect in the TAA liver cirrhosis model. Further investigations on mechanisms of α-mangostin as therapeutic agent should be determined. © 2015, Medical Association of Thailand. All rights reserved. |
|
dc.subject |
alanine aminotransferase |
|
dc.subject |
alpha mangostin |
|
dc.subject |
aspartate aminotransferase |
|
dc.subject |
beta actin |
|
dc.subject |
collagen type 1 |
|
dc.subject |
inducible nitric oxide synthase |
|
dc.subject |
interleukin 1beta |
|
dc.subject |
plant medicinal product |
|
dc.subject |
protein p53 |
|
dc.subject |
thioacetamide |
|
dc.subject |
tumor necrosis factor alpha |
|
dc.subject |
unclassified drug |
|
dc.subject |
alanine aminotransferase |
|
dc.subject |
aspartate aminotransferase |
|
dc.subject |
mangostin |
|
dc.subject |
thioacetamide |
|
dc.subject |
xanthone derivative |
|
dc.subject |
animal model |
|
dc.subject |
animal tissue |
|
dc.subject |
Article |
|
dc.subject |
chemoluminescence |
|
dc.subject |
controlled study |
|
dc.subject |
gene expression |
|
dc.subject |
gene sequence |
|
dc.subject |
liver cirrhosis |
|
dc.subject |
liver fibrosis |
|
dc.subject |
male |
|
dc.subject |
nonhuman |
|
dc.subject |
protein expression |
|
dc.subject |
rat |
|
dc.subject |
reverse transcription polymerase chain reaction |
|
dc.subject |
signal transduction |
|
dc.subject |
Western blotting |
|
dc.subject |
animal |
|
dc.subject |
blood |
|
dc.subject |
liver cirrhosis |
|
dc.subject |
Wistar rat |
|
dc.subject |
Alanine Transaminase |
|
dc.subject |
Animals |
|
dc.subject |
Aspartate Aminotransferases |
|
dc.subject |
Liver Cirrhosis |
|
dc.subject |
Male |
|
dc.subject |
Rats |
|
dc.subject |
Rats, Wistar |
|
dc.subject |
Thioacetamide |
|
dc.subject |
Xanthones |
|
dc.title |
Investigation of therapeutic effects of α-mangostin on thioacetamide-induced cirrhosis in rats |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Journal of the Medical Association of Thailand. Vol 98, (2015), p.S91-S97 |
|