| dc.contributor.author |
Awale S. |
|
| dc.contributor.author |
Tawila A.M. |
|
| dc.contributor.author |
Dibwe D.F. |
|
| dc.contributor.author |
Ueda J.-Y. |
|
| dc.contributor.author |
Sun S. |
|
| dc.contributor.author |
Athikomkulchai S. |
|
| dc.contributor.author |
Balachandran C. |
|
| dc.contributor.author |
Saiki I. |
|
| dc.contributor.author |
Matsumoto K. |
|
| dc.contributor.author |
Esumi H. |
|
| dc.date.accessioned |
2021-04-05T03:23:09Z |
|
| dc.date.available |
2021-04-05T03:23:09Z |
|
| dc.date.issued |
2017 |
|
| dc.identifier.issn |
0960894X |
|
| dc.identifier.other |
2-s2.0-85015942234 |
|
| dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/13297 |
|
| dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015942234&doi=10.1016%2fj.bmcl.2017.03.021&partnerID=40&md5=5984c6328985a72cbb5aeb226472c166 |
|
| dc.description.abstract |
From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM). © 2017 Elsevier Ltd |
|
| dc.subject |
antineoplastic agent |
|
| dc.subject |
cyclohexene derivative |
|
| dc.subject |
unclassified drug |
|
| dc.subject |
uvaridacol i |
|
| dc.subject |
uvaridacol j |
|
| dc.subject |
uvaridacol k |
|
| dc.subject |
uvaridacol l |
|
| dc.subject |
antineoplastic agent |
|
| dc.subject |
cyclohexene |
|
| dc.subject |
cyclohexene derivative |
|
| dc.subject |
oxygen |
|
| dc.subject |
Article |
|
| dc.subject |
Capan 1 cell line |
|
| dc.subject |
carbon nuclear magnetic resonance |
|
| dc.subject |
circular dichroism |
|
| dc.subject |
cytotoxicity |
|
| dc.subject |
drug potency |
|
| dc.subject |
heteronuclear multiple bond correlation |
|
| dc.subject |
human |
|
| dc.subject |
human cell |
|
| dc.subject |
KLM 1 cell line |
|
| dc.subject |
nuclear magnetic resonance spectroscopy |
|
| dc.subject |
nuclear Overhauser effect |
|
| dc.subject |
PaCa 2 cell line |
|
| dc.subject |
PANC 1 cell line |
|
| dc.subject |
pancreatic cancer cell line |
|
| dc.subject |
plant leaf |
|
| dc.subject |
proton nuclear magnetic resonance |
|
| dc.subject |
PSN 1 cell line |
|
| dc.subject |
Uvaria |
|
| dc.subject |
Uvaria dac |
|
| dc.subject |
chemistry |
|
| dc.subject |
drug effects |
|
| dc.subject |
drug screening |
|
| dc.subject |
isolation and purification |
|
| dc.subject |
pancreas |
|
| dc.subject |
Pancreatic Neoplasms |
|
| dc.subject |
plant leaf |
|
| dc.subject |
tumor cell line |
|
| dc.subject |
Uvaria |
|
| dc.subject |
Antineoplastic Agents, Phytogenic |
|
| dc.subject |
Cell Line, Tumor |
|
| dc.subject |
Cyclohexenes |
|
| dc.subject |
Drug Screening Assays, Antitumor |
|
| dc.subject |
Humans |
|
| dc.subject |
Oxygen |
|
| dc.subject |
Pancreas |
|
| dc.subject |
Pancreatic Neoplasms |
|
| dc.subject |
Plant Leaves |
|
| dc.subject |
Uvaria |
|
| dc.title |
Highly oxygenated antiausterity agents from the leaves of Uvaria dac |
|
| dc.type |
Article |
|
| dc.rights.holder |
Scopus |
|
| dc.identifier.bibliograpycitation |
Bioorganic and Medicinal Chemistry Letters. Vol 27, No.9 (2017), p.1967-1971 |
|
| dc.identifier.doi |
10.1016/j.bmcl.2017.03.021 |
|