dc.contributor.author |
Gerdprasert O. |
|
dc.contributor.author |
Choomchuay N. |
|
dc.contributor.author |
Chantong B. |
|
dc.contributor.author |
Sutanthavibul N. |
|
dc.contributor.author |
Meksuriyen D. |
|
dc.contributor.author |
Nusuetrong P. |
|
dc.date.accessioned |
2021-04-05T03:04:23Z |
|
dc.date.available |
2021-04-05T03:04:23Z |
|
dc.date.issued |
2019 |
|
dc.identifier.issn |
1741427X |
|
dc.identifier.other |
2-s2.0-85073078632 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/12604 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073078632&doi=10.1155%2f2019%2f4823645&partnerID=40&md5=a21832711209112cb0d6f5353f0ff099 |
|
dc.description.abstract |
Phikud Navakot (PN) is nine major herbs in a famous traditional Thai recipe namely "Yahom Navakot" used to treat cardiovascular disorders. This study investigated the cardioprotective effects of PN formula on isoproterenol-induced myocardial infarction (IMI) in Sprague-Dawley rats. Forty-five rats were randomly divided into nine groups (n = 5 per group): the control, the IMI, the IMI + propranolol, the control or the IMI + PN formula (PN ethanolic extract at doses of 64, 127, or 255 mg/kg) by oroesophageal gavage for 28 days. The ST segment and serum troponin T levels were significantly increased in IMI rats. PN did not eliminate tissue necrosis, infiltration of inflammatory cells, or interstitial edema in IMI rats. All doses of PN decreased (p<0.001) serum TNF-α and IL-6 levels. PN (127 and 255 mg/kg) up-regulated (p<0.05) heme oxygenase (HO)-1 expression, whereas PN (255 mg/kg) significantly increased superoxide dismutase (SOD) 1 and 2 expression, compared with IMI rats. Nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 expression significantly increased in IMI rats and IMI rats that received PN. PN formula possesses potential anti-inflammatory and antioxidant properties by modulating the levels of TNF-α, IL-6 and antioxidant enzymes. Our study reveals a novel cardioprotective effect of PN in IMI rats through the Nrf2/HO-1 signaling. © 2019 Orapin Gerdprasert et al. |
|
dc.subject |
alcohol |
|
dc.subject |
antiinflammatory agent |
|
dc.subject |
antioxidant |
|
dc.subject |
cardiovascular agent |
|
dc.subject |
catalase |
|
dc.subject |
copper zinc superoxide dismutase |
|
dc.subject |
glutathione peroxidase |
|
dc.subject |
heme oxygenase 1 |
|
dc.subject |
herbaceous agent |
|
dc.subject |
interleukin 6 |
|
dc.subject |
manganese superoxide dismutase |
|
dc.subject |
phikud navakot |
|
dc.subject |
propranolol |
|
dc.subject |
protective agent |
|
dc.subject |
transcription factor Nrf2 |
|
dc.subject |
troponin T |
|
dc.subject |
tumor necrosis factor |
|
dc.subject |
unclassified drug |
|
dc.subject |
acute heart infarction |
|
dc.subject |
animal experiment |
|
dc.subject |
animal model |
|
dc.subject |
animal tissue |
|
dc.subject |
antiinflammatory activity |
|
dc.subject |
antioxidant activity |
|
dc.subject |
Article |
|
dc.subject |
cell infiltration |
|
dc.subject |
controlled study |
|
dc.subject |
cytokine release |
|
dc.subject |
drug dose comparison |
|
dc.subject |
drug efficacy |
|
dc.subject |
drug mechanism |
|
dc.subject |
edema |
|
dc.subject |
enzyme activity |
|
dc.subject |
ethnopharmacology |
|
dc.subject |
heart muscle injury |
|
dc.subject |
heart muscle necrosis |
|
dc.subject |
heart protection |
|
dc.subject |
heart tissue |
|
dc.subject |
inflammation |
|
dc.subject |
inflammatory cell |
|
dc.subject |
inflammatory infiltrate |
|
dc.subject |
interstitial edema |
|
dc.subject |
isoproterenol-induced myocardial infarction |
|
dc.subject |
male |
|
dc.subject |
mediator release |
|
dc.subject |
nonhuman |
|
dc.subject |
oxidative stress |
|
dc.subject |
protein blood level |
|
dc.subject |
protein expression |
|
dc.subject |
rat |
|
dc.subject |
signal transduction |
|
dc.subject |
ST segment |
|
dc.subject |
tissue necrosis |
|
dc.subject |
upregulation |
|
dc.title |
Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Evidence-based Complementary and Alternative Medicine. Vol 2019, (2019) |
|
dc.identifier.doi |
10.1155/2019/4823645 |
|