dc.contributor.author |
Chuysinuan P. |
|
dc.contributor.author |
Pengsuk C. |
|
dc.contributor.author |
Lirdprapamongkol K. |
|
dc.contributor.author |
Techasakul S. |
|
dc.contributor.author |
Svasti J. |
|
dc.contributor.author |
Nooeaid P. |
|
dc.date.accessioned |
2021-04-05T03:04:20Z |
|
dc.date.available |
2021-04-05T03:04:20Z |
|
dc.date.issued |
2019 |
|
dc.identifier.issn |
12299197 |
|
dc.identifier.other |
2-s2.0-85061651018 |
|
dc.identifier.uri |
https://ir.swu.ac.th/jspui/handle/123456789/12593 |
|
dc.identifier.uri |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061651018&doi=10.1007%2fs12221-019-8753-y&partnerID=40&md5=add8172adacf4e150d7410a6e8be1957 |
|
dc.description.abstract |
Tissue engineering involves a multifunctional temporary matrix which regulates tissue regeneration through controlled drug release against infections. A nanofibrous core-sheath structured scaffold comprising a tetracycline-loaded alginate/soy protein isolate (TCH-Alg/SPI) as a core and polycaprolactone (PCL) as a sheath was developed using co-axial electrospinning. Coverage of hydrophobic PCL on TCH-Alg/SPI fibers enhanced their structural stability in aqueous solutions as unsheathed fibers rapidly decomposed and provided fast drug release. Core-sheath fibers exhibited an initial burst release at ~49 % after 6 h of immersion in phosphate-buffered saline (PBS) solution and the sustain release reached ~80 % of total loaded drug on day 14. Release characteristics of TCH-Alg/SPI fibers without PCL covering showed immediate drug release within 48 h. Core-sheath fibers investigated by disk diffusion exhibited antibacterial properties against Staphylococcus aureus and Escherichia coli. The non-toxicity of core-sheath fibers was confirmed by an indirect cytotoxicity test using human dermal fibroblasts which showed compatibility and high cell viability of up to 100 % in treated cells. TCH-Alg/SPI-PCL core-sheath fibers show promise as tissue engineering scaffolds which can act as temporary templates for tissue regeneration and exhibit antibiotic release functions against infections caused by pathogenic microorganisms. © 2019, The Korean Fiber Society, The Korea Science and Technology Center. |
|
dc.subject |
Antibiotics |
|
dc.subject |
Cell culture |
|
dc.subject |
Cytotoxicity |
|
dc.subject |
Electrospinning |
|
dc.subject |
Escherichia coli |
|
dc.subject |
Fibers |
|
dc.subject |
Proteins |
|
dc.subject |
Scaffolds (biology) |
|
dc.subject |
Stability |
|
dc.subject |
Targeted drug delivery |
|
dc.subject |
Tissue |
|
dc.subject |
Tissue engineering |
|
dc.subject |
Tissue regeneration |
|
dc.subject |
Antibacterial properties |
|
dc.subject |
Coaxial electrospinning |
|
dc.subject |
Core sheaths |
|
dc.subject |
Drug release |
|
dc.subject |
Pathogenic microorganisms |
|
dc.subject |
Phosphate buffered saline solutions |
|
dc.subject |
Tissue engineering applications |
|
dc.subject |
Tissue engineering scaffold |
|
dc.subject |
Controlled drug delivery |
|
dc.subject |
Antibiotics |
|
dc.subject |
Cores |
|
dc.subject |
Engineering |
|
dc.subject |
Fibers |
|
dc.subject |
Proteins |
|
dc.subject |
Release |
|
dc.subject |
Stability |
|
dc.subject |
Tissue |
|
dc.title |
Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications |
|
dc.type |
Article |
|
dc.rights.holder |
Scopus |
|
dc.identifier.bibliograpycitation |
Fibers and Polymers. Vol 20, No.1 (2019) |
|
dc.identifier.doi |
10.1007/s12221-019-8753-y |
|