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Browsing by Subject "p38 Mitogen-Activated Protein Kinases"

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Anti-metastatic effect of rhodomyrtone from Rhodomyrtus tomentosa on human skin cancer cells

Tayeh M.; Nilwarangoon S.; Mahabusarakum W.; Watanapokasin R. (2017)

This study focused on the inhibitory effect of rhodomyrtone, a bioactive compound isolated from the leaves of Rhodomyrtus tomentosa (Aiton) Hassk., on cancer metastasis in epidermoid carcinoma A431 cells and on the ...
Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells

Nusuetrong P.; Saito M.; Kikuchi H.; Oshima Y.; Moriya T.; Nakahata N. (2012)

Satratoxin H is an important air- and food-borne mycotoxin, which has been implicated in human health damage. Satratoxin H is known to induce apoptosis as well as genotoxicity in PC12 cells. In the present study, we further ...
Concurrent suppression of NF-κB, p38 MAPK and reactive oxygen species formation underlies the effect of a novel compound isolated from Curcuma comosa Roxb. in LPS-activated microglia

Jiamvoraphong N.; Jantaratnotai N.; Sanvarinda P.; Tuchinda P.; Piyachaturawat P.; Thampithak A.; Sanvarinda P. (2017)

Objective: We investigated the molecular mechanisms underlying the effect of (3S)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol, also known as compound 092, isolated from Curcuma comosa Roxb on the production of ...
P38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells

Chowchaikong N.; Nilwarangkoon S.; Laphookhieo S.; Tanunyutthawongse C.; Watanapokasin R. (2018)

Colorectal cancer, which is the third most common type of cancer diagnosed in both men and women, is the leading cause of cancer-related deaths worldwide. Cowanin is a pure compound extracted from Garcinia cowa Roxb., a ...
RUNX1 Regulates Migration, Invasion, and Angiogenesis via p38 MAPK Pathway in Human Glioblastoma

Sangpairoj K.; Vivithanaporn P.; Apisawetakan S.; Chongthammakun S.; Sobhon P.; Chaithirayanon K. (2017)

Runt-related transcription factor 1 (RUNX1) is essential for the establishment of fetal and adult hematopoiesis and neuronal development. Aberrant expression of RUNX1 led to proliferation and metastasis of several cancers. ...
Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells

Nusuetrong P.; Pengsuparp T.; Meksuriyen D.; Tanitsu M.; Kikuchi H.; Mizugaki M.; Shimazu K.-I.; Oshima Y.; Nakahata N.; Yoshida M. (2008)

Satratoxin H, a mycotoxin, is thought to induce apoptosis of PC12 cells through the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) in a glutathione (GSH)-sensitive manner. The ...

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