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Browsing by Subject "concentration response"

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Acute inhibitory effect of alpha-mangostin on sarcoplasmic reticulum calcium-ATPase and myocardial relaxation

Phungphong S.; Kijtawornrat A.; de Tombe P.P.; Wattanapermpool J.; Bupha-Intr T.; Suksamrarn S. (2017)

The benefits of α-mangostin for various tissues have been reported, but its effect on the heart has not been clarified. This study aimed to evaluate the effects of α-mangostin on cardiac function. Using a cardiac sarcoplasmic ...
Anticancer and apoptosis-inducing activities of microbial metabolites

Phonnok S.; Tanechpongtamb W.U.; Wongsatayanon B.T. (2010)

The problems of systemic toxicity and drug resistance in cancer chemotherapy urge the continuing discovery of new anticancer agents. We explored the specific anticancer activity from microbial metabolites to find new lead ...
Antiproliferative effect of α-mangostin on canine osteosarcoma cells

Krajarng A.; Nilwarankoon S.; Suksamrarn S.; Watanapokasin R. (2012)

Osteosarcoma is the most frequently diagnosed primary bone tumor in dog. Since chemotherapeutics are quite limited due to high cost and severe toxicity, therefore, the ultimate goal is to discover cost-effective therapeutics ...
Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid

Krajarng A.; Imoto M.; Tashiro E.; Fujimaki T.; Shinjo S.; Watanapokasin R. (2015)

Background: Gambogic acid (GA) was extracted from the dried yellow resin of gamboge (Garcinia hanburyi) which is traditionally used as a coloring material for painting and cloth dying. Gamboge has been also used as a folk ...
Barakol extracted from cassia siamea stimulates chloride secretion in rat colon

Deachapunya C.; Poonyachoti S.; Thongsaard W.; Krishnamra N. (2005)

Barakol is a purified extract of Cassia siamea, a plant that has been used as a laxative in traditional medicine. In this study, the effect of barakol on anion transport across the rat colon epithelium was investigated. ...
Barakol suppresses norepinephrine-induced inhibition of spontaneous longitudinal smooth muscle contractions in isolated rat small intestine

Deachapunya C.; Thongsaard W.; Poonyachoti S. (2005)

The present study aimed to investigate the purgative effects of barakol, the purified extract of Cassia siamea Lam., on the longitudinal smooth muscle contractions of the rat ileum. The extract increased the force of ...
Bioactive constituents of the root bark of Artocarpus rigidus subsp. rigidus

Namdaung U.; Aroonrerk N.; Suksamrarn S.; Danwisetkanjana K.; Saenboonrueng J.; Arjchomphu W.; Suksamrarn A. (2006)

Investigation of the chemical constituents of the root bark of Artocarpus rigidus BLUME subsp. rigidus has led to the isolation of six, structurally diverse phenolic compounds. These included two new compounds with modified ...
Bioproduction and anticancer activity of biosurfactant produced by the dematiaceous fungus Exophiala dermatitidis SK80

Chiewpattanakul P.; Phonnok S.; Durand A.; Marie E.; Thanomsub B.W. (2010)

A new biosurfactant producer was isolated from palm-oilcontaminated soil and later identified through morphology and DNA sequencing as the yeast-like fungus Exophiala dermatitidis. Biosurfactant production was catalyzed ...
Chrysin inhibits lymphangiogenesis in vitro

Prangsaengtong O.; Athikomkulchai S.; Xu J.; Koizumi K.; Inujima A.; Shibahara N.; Shimada Y.; Tadtong S.; Awale S. (2016)

The induction of lymphangiogenesis is an important process to promote cancer growth and cancer metastasis via the lymphatic system. Identifying the compounds that can prevent lymphangiogenesis for cancer therapy is urgently ...
Curcumin and tetrahydrocurcumin restore the impairment of endothelium-dependent vasorelaxation induced by homocysteine thiolactone in rat aortic rings

Tep-Areenan P.; Suksamrarn A. (2012)

The aim of the present study was to investigate the effects of curcumin and Terra Hydro Curcumin (THC) on the inhibition of endothelium-dependent vasorelaxation of the isolated rat aorta by Homocysteine Thiolactone (HTL). ...
Disposition of chloroform in phosphatidylcholine membranes: A 2H- and 31P-NMR study

Phonphok N.; Chidichimo G.; Westerman P.W. (1996)

The interaction of chloroform with bilayers of dimyristoylphosphatidylcholine (DMPC) has been studied by deuterium and phosphorus-31 nuclear magnetic resonance (NMR). Orientational order has been measured as a function of ...
Effects of naofen on enzyme activities of serine proteases and matrix metallo-p roteinases

Wongsawatkul O.; Feng G.-G.; Li C.; Huang L.; Kondo F.; Kurokawa S.; Fujiwara Y.; Ishikawa N. (2011)

The aim of this study was to investigate whether naofen affected on the activities of metallo and serine proteases. Naofen, found in both intra- and extra-cellular spaces, increased in the livers especially under pathological ...
Effects of Phikud Navakot extract on vascular reactivity in the isolated rat aorta

Nusuetrong P.; Sotanaphun U.; Tep-Areenan P. (2012)

The aim of the present study is to investigate the effect of standardized Phikud Navakot extract (NVKE) on aortic rings from male Sprague Dawley rats. Changes in tension were measured using an isometric force transducer ...
(+)-Grandiforacin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

Ueda J.-Y.; Athikomkulchai S.; Miyatake R.; Saiki I.; Esumi H.; Awale S. (2013)

Human pancreatic tumors are known to be highly resistant to nutrient starvation, and this prolongs their survival in the hypovascular (austere) tumor microenvironment. Agents that retard this tolerance to nutrient starvation ...
Growth inhibition and chemosensitization of human carcinoma cells by human serum albumin-coated liposomal antisense oligodeoxyribonucleotide against bcl-2

Weecharangsan W.; Lee R.J. (2012)

Previous study has shown human serum albumin (HSA) coated liposomes can deliver bcl-2 antisense oligodeoxyribonucleotide (ODN) into KB carcinoma cells, and decrease bcl-2 mRNA and protein expression level. In the current ...
Highly selective and sensitive paper-based colorimetric sensor using thiosulfate catalytic etching of silver nanoplates for trace determination of copper ions

Chaiyo S.; Siangproh W.; Apilux A.; Chailapakul O. (2015)

A novel, highly selective and sensitive paper-based colorimetric sensor for trace determination of copper (Cu2+) ions was developed. The measurement is based on the catalytic etching of silver nanoplates (AgNPls) by ...
Holothuria scabra Extract Induces Cell Apoptosis and Suppresses Warburg Effect by Down-Regulating Akt/mTOR/HIF-1 Axis in MDA-MB-231 Breast Cancer Cells

Yurasakpong L.; Apisawetakan S.; Pranweerapaiboon K.; Sobhon P.; Chaithirayanon K. (2021)

Introduction: Cancer cells utilize the modified glucose metabolism known as Warburg effect, with lactate production as the end product. In the search for alternative therapy, the body wall of sea cucumbers contains various ...
Influence of microenvironment and liposomal formulation on secondary structure and bilayer interaction of lysozyme

Witoonsaridsilp W.; Panyarachun B.; Sarisuta N.; Müller-Goymann C.C. (2010)

The conformation of peptide and protein drugs in various microenvironments and the interaction with drug carriers such as liposomes are of considerable interest. In this study the influence of microenvironments such as pH, ...
Investigation on biological activities of anthranilic acid sulfonamide analogs

Doungsoongnuen S.; Worachartcheewan A.; Pingaew R.; Suksrichavalit T.; Prachayasittikul S.; Ruchirawat S.; Prachayasittikul V. (2011)

In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. ...
Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells

Wattanapitayakul S.K.; Suwatronnakorn M.; Chularojmontri L.; Herunsalee A.; Niumsakul S.; Charuchongkolwongse S.; Chansuvanich N. (2007)

The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. This study investigated effect of ...

Now showing items 1-20 of 35

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