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Browsing by Subject "ascorbic acid"

Now showing items 1-20 of 23

Antioxidant, aα-glucosidase inhibitory activity and sub-chronic toxicity of Derris reticulata extract: Its antidiabetic potential

Kumkrai P.; Weeranantanapan O.; Chudapongse N. (2015)

Background: Antidiabetic activity of Derris reticulata extract on alloxan-induced diabetic rats has been reported. The extract was found to lower blood glucose and inhibit intestinal glucose absorption. The aim of this ...
Antioxidative and cardioprotective effects of Phyllanthus urinaria L. on doxorubicin-induced cardiotoxicity

Chularojmontri L.; Wattanapitayakul S.K.; Herunsalee A.; Charuchongkolwongse S.; Niumsakul S.; Srichairat S. (2005)

Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy. Many recent studies have shown that DOX toxicity involves generation of reactive oxygen species (ROS). Although protection or alleviation of ...
Application of modifier-free gold nanoparticle colorimetric sensing for rapid screening and detection of vitamin B1

Duenchay P.; Kaewjua K.; Chailapakul O.; Siangproh W. (2020)

In this report, we present a transparency sheet-based colorimetric sensor as an alternative platform for the simple, sensitive and selective determination of vitamin B1 in urine samples by using unmodified gold nanoparticles ...
Carotenoid intake and asthma prevalence in Thai children

Rerksuppaphol S.; Rerksuppaphol L. (2012)

Several antioxidant nutrients have been described to inversely correlate with asthma. In order to quantify the intake of these substances, it is possible to measure skin levels by Raman spectroscopy, a novel non-invasive ...
Correlations between endothelial functions and ros detection in diabetic microvascular wall: Early and late ascorbic acid supplementation

Sridulyakul P.; Wongeak-In N.; Patumraj S. (2012)

The correlation between endothelial function and reactive oxygen species detecting from diabetic microvascular wall and the antioxidant effect of ascorbic acid (AA) during early and late phases of diabetic induction were ...
Cratoxylum formosum Extract Protects against Amyloid-Beta Toxicity in a Caenorhabditis elegans Model of Alzheimer's Disease

Keowkase R.; Weerapreeyakul N. (2016)

Amyloid-β, one of the hallmarks of Alzheimer's disease, is toxic to neurons and causes cell death in the brain. Oxidative stress is known to play an important role in Alzheimer's disease, and there is strong evidence linking ...
Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment

Sawutdeechaikul P.; Kanokrungsee S.; Sahaspot T.; Thadvibun K.; Banlunara W.; Limcharoen B.; Sansureerungsikul T.; Rutwaree T.; Oungeun M.; Wanichwecharungruang S. (2021)

Delivering bioactive compounds into skin tissue has long been a challenge. Using ex vivo porcine and rat skins, here we demonstrate that a detachable dissolvable microneedle (DDMN) array, a special dissolvable microneedle ...
Effect of Partial Replacement of Sucrose With Humectant in the Osmotic Solution on the Characteristics of Osmo-Dried Cantaloupe

Naknaen P.; Maneyam R.; Kam-Onsri A. (2016)

The effect of osmotic solutions consisting of sucrose and humectants (sorbitol and glucose syrup) on the quality of osmo-dried cantaloupe was investigated. The ratios between sucrose and each humectant were varied (90:10, ...
Effects of oxyresveratrol and its derivatives on cultured P19-derived neurons

Tadtong S.; Chatsumpun N.; Sritularak B.; Jongbunprasert V.; Ploypradith P.; Likhitwitayawuid K. (2016)

Purpose: To modify the structure of oxyresveratrol and evaluate the obtained derivatives for effects on neuronal cells. Methods: Electron-withdrawing groups were selectively introduced to the aromatic ring of the core ...
Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study

Jaturapisanukul K.; Udompataikul M.; Kanokrungsee S.; Rojhirunsakool S.; Kamanamool N.; Rachpirom M.; Puttarak P. (2021)

Acne vulgaris is a chronic inflammatory skin disease. Antibiotics, particularly clindamycin and erythromycin, are used for the treatment of acne vulgaris. However, emerging antibiotic-resistant strains have been an important ...
Highly stable and fast-dissolving ascorbic acid-loaded microneedles

Leelawattanachai J.; Panyasu K.; Prasertsom K.; Manakasettharn S.; Duangdaw H.; Budthong P.; Thepphornbanchakit N.; Chetprayoon P.; Muangnapoh K.; Srinives S.; Waraho-Zhmayev D.; Triampo D. (John Wiley and Sons Inc, 2023)

Objectives: Ascorbic acid has many benefits to the skin. Numerous attempts to promote its topical delivery show great challenges since its chemical instability and poor skin impermeability. Microneedle delivery is a simple, ...
Neurite outgrowth and neuroprotective effects of quercetin from caesalpinia mimosoides lamk. on CULTURED P19-derived neurons

Tangsaengvit N.; Kitphati W.; Tadtong S.; Bunyapraphatsara N.; Nukoolkarn V. (2013)

Quercetin has been isolated for the first time from ethyl acetate extract of Caesalpinia mimosoides Lamk. C. mimosoides Lamk. (Fabaceae) or Cha rueat (Thai name) is an indigenous plant found in mixed deciduous forest in ...
Neuritogenic and neuroprotective activities of the essential oil from rhizomes of curcuma alismatifolia

Kochaphum S.; Banyat P.; Tadtong S.; Sareedenchai V.; Athikomkulchai S. (2019)

The essential oil from rhizomes of Curcuma alismatifolia Gagnep. was extracted by hydrodistillation. Chemical analysis by gas chromatography- mass spectrometry identified 12 compounds, of which the most prominent were ...
Novel multifunctional ascorbic triazole derivatives for amyloidogenic pathway inhibition, anti-inflammation, and neuroprotection

Jiaranaikulwanitch J.; Pandith H.; Tadtong S.; Thammarat P.; Jiranusornkul S.; Chauthong N.; Nilkosol S.; Vajragupta O. (2021)

Alzheimer’s disease (AD) is a common neurodegenerative disorder. The number of patients with AD is projected to reach 152 million by 2050. Donepezil, rivastigmine, galantamine, and memantine are the only four drugs currently ...
Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications

Wattanapitayakul S.K.; Bauer J.A. (2001)

Despite some recent declines, cardiovascular disease (CVD) remains the major cause of death in the United States and worldwide. Most recent advances in the treatment of CVD states have been produced by inhibition of ...
Protection against cisplatin-induced nephrotoxicity in mice by Curcuma comosa Roxb. ethanol extract

Jariyawat S.; Kigpituck P.; Suksen K.; Chuncharunee A.; Chaovanalikit A.; Piyachaturawat P. (2009)

The protective effect of an ethanol extract of Curcuma comosa against cisplatin-induced renal toxicity in mice was studied. Adult male mice were pretreated for 4 days with the ethanol extract of C. comosa [100-200 mg/kg ...
Pummelo protects doxorubicin-induced cardiac cell death by reducing oxidative stress, modifying glutathione transferase expression, and preventing cellular senescence

Chularojmontri L.; Gerdprasert O.; Wattanapitayakul S.K. (2013)

Citrus flavonoids have been shown to reduce cardiovascular disease (CVD) risks prominently due to their antioxidant effects. Here we investigated the protective effect of pummelo (Citrus maxima, CM) fruit juice in rat ...
Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity

Wattanapitayakul S.K.; Chularojmontri L.; Herunsalee A.; Charuchongkolwongse S.; Niumsakul S.; Bauer J.A. (2005)

Doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. Elevated tissue levels of cellular ...
Screening of potential tropical fruits in protecting endothelial dysfunction in vitro

Wattanapitayakul S.K.; Kunchana K.; Jarisarapurin W.; Chularojmontri L. (2021)

Background: High consumption of antioxidant-rich fruits and vegetables reduces the endothelial damage in-volved in cardiovascular disease pathogenesis. Objective: To evaluate the phytochemical content, antioxidant and ...
Selected activities of Citrus Maxima merr. Fruits on human endothelial cells: Enhancing cell migration and delaying cellular aging

Buachan P.; Chularojmontri L.; Wattanapitayakul S.K. (2014)

Endothelial injury and damage as well as accumulated reactive oxygen species (ROS) in aging play a significant role in the development of cardiovascular disease (CVD). Recent studies show an association of high citrus fruit ...

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