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Browsing by Subject "C57BL mouse"

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17β-Estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult

Tripanichkul W.; Sripanichkulchai K.; Duce J.A.; Finkelstein D.I. (2007)

Emerging evidence suggests the beneficial effects of estrogen on Parkinson's disease (PD), yet the mechanisms of action implicated remain elusive. While experimental evidence suggests that estrogen possesses potent ...
Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract

Pan-In P.; Tachapruetinun A.; Chaichanawongsaroj N.; Banlunara W.; Suksamrarn S.; Wanichwecharungruang S. (2014)

Aim: To combat the resistance of Helicobacter pylori to antibiotics through the use of Garcinia mangostana extract (GME) in the form that can be localized at stomach mucosa. Materials & methods: GME and its major active ...
Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice

Gutierrez-Orozco F.; Thomas-Ahner J.M.; Berman-Booty L.D.; Galley J.D.; Chitchumroonchokchai C.; Mace T.; Suksamrarn S.; Bailey M.T.; Clinton S.K.; Lesinski G.B.; Failla M.L. (2014)

Scope: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. α-Mangostin (α-MG), the most abundant xanthone in mangosteen fruit, exerts anti-inflammatory and antibacterial activities in vitro. We evaluated ...
Effects of intramuscular administration of 1α,25(OH)2D3 during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis

Srikuea R.; Hirunsai M. (2016)

The recent discovery of the vitaminDreceptor (VDR) in regenerating muscle raises the question regarding the action of Vitamin D3 on skeletal muscle regeneration. To investigate the action of Vitamin D3 on this process, the ...
Estrogen increases striatal GDNF immunoreactivity with no effect on striatal FGF-2 immunoreactivity of MPTP-treated mice

Tripanichkul W.; Jaroensuppaperch E.O. (2015)

Background: Glial derived neurotrophic factor (GDNF) and basic fibroblast growth factor (FGF-2) protect nigrostriatal dopaminergic (DA) neurons and their projections in animal models of Parkinson’s disease (PD). Recent ...
Melatonin attenuates methamphetamine-induced inhibition of neurogenesis in the adult mouse hippocampus: An in vivo study

Singhakumar R.; Boontem P.; Ekthuwapranee K.; Sotthibundhu A.; Mukda S.; Chetsawang B.; Govitrapong P. (2015)

Methamphetamine (METH), a highly addictive psychostimulant drug, is known to exert neurotoxic effects to the dopaminergic neural system. Long-term METH administration impairs brain functions such as cognition, learning and ...
Porphyromonas gingivalis elevated high-mobility group box 1 levels after myocardial infarction in mice

Srisuwantha R.; Shiheido Y.; Aoyama N.; Sato H.; Kure K.; Laosrisin N.; Izumi Y.; Suzuki J.-I. (2017)

High mobility group box 1 (HMGB1) is a nuclear protein released from necrotic cells, inducing inflammatory responses. Epidemiological studies suggested a possible association between periodontitis and cardiovascular diseases ...
Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation

Loison F.; Zhu H.; Karatepe K.; Kasorn A.; Liu P.; Ye K.; Zhou J.; Cao S.; Gong H.; Jenne D.E.; Remold-O'Donnell E.; Xu Y.; Luo H.R. (2014)

Caspase-3-mediated spontaneous death in neutrophils is a prototype of programmed cell death and is critical for modulating physiopathological inflammatory responses; however, the underlying regulatory pathways remain ill ...
Rat β3-adrenoceptor protein expression: Antibody validation and distribution in rat gastrointestinal and urogenital tissues

Cernecka H.; Pradidarcheep W.; Lamers W.H.; Schmidt M.; Michel M.C. (2014)

β3-Adrenoceptors play important roles in the regulation of urogenital and probably gastrointestinal function. However, despite recent progress, their detection at the protein level has remained difficult due to a lack of ...
Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing

Srikuea R.; Hirunsai M.; Charoenphandhu N. (2020)

Skeletal muscle exhibits enormous plasticity throughout life, however, less is known regarding how the stages of growth regulate its local vitamin D system. Herein, we investigated serum 25(OH)D3 and Ca2+ levels along with ...
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms

Osataphan S.; Macchi C.; Singhal G.; Chimene-Weiss J.; Sales V.; Kozuka C.; Dreyfuss J.M.; Pan H.; Tangcharoenpaisan Y.; Morningstar J.; Gerszten R.; Patti M.-E. (2019)

Pharmacologic inhibition of the renal sodium/glucose cotransporter-2 induces glycosuria and reduces glycemia. Given that SGLT2 inhibitors (SGLT2i) reduce mortality and cardiovascular risk in type 2 diabetes, improved ...

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