Browsing by Subject "1,2,3 triazole derivative"

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Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents

Prachayasittikul S.; Pingaew R.; Worachartcheewan A.; Sinthupoom N.; Prachayasittikul V.; Ruchirawat S.; Prachayasittikul V. (2017)

Background: Cancer has been considered to be a global health concern due to the impact of disease on the quality of life. The continual increase of cancer cases as well as the resistance of cancer cells to the existing ...
Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors

Pingaew R.; Prachayasittikul V.; Mandi P.; Nantasenamat C.; Prachayasittikul S.; Ruchirawat S.; Prachayasittikul V. (2015)

Abstract A series of 1,4-disubstituted-1,2,3-triazoles (13-35) containing sulfonamide moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles with open-chain sulfonamide showed significant ...
Synthesis, biological evaluation and molecular docking of novel chalcone-coumarin hybrids as anticancer and antimalarial agents

Pingaew R.; Saekee A.; Mandi P.; Nantasenamat C.; Prachayasittikul S.; Ruchirawat S.; Prachayasittikul V. (2014)

A new series of chalcone-coumarin derivatives (9-19) linked by the 1,2,3-triazole ring were synthesized through the azide/alkyne dipolar cycloaddition. Hybrid molecules were evaluated for their cytotoxic activity against ...

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