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Browsing by Author "Vajragupta O."

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Antiangiogenic effects of VH02, a novel urea derivative: In vitro and in vivo studies

Phowichit S.; Kobayashi M.; Fujinoya Y.; Sato Y.; Sanphanya K.; Vajragupta O.; Chularojmontri L.; Wattanapitayakul S.K. (2016)

Vascular endothelial growth factor receptor 2 (VEGFR2) is a vital target for therapeutic intervention in cancer. We have recently described a computer-based drug design for a small molecule VEGFR2 inhibitor named VH02 ...
Antifungal, cytotoxic activities and docking studies of 2,5-dimercapto-1,3,4-thiadiazole derivatives

Samee W.; Vajragupta O. (2011)

A series of 2,5-dimercapto-1,3,4-thiadiazole derivatives (compounds 1 to 10) were prepared by nucleophilic substitution reaction between 2,5-dimercapto-1,3,4-thiadiazole and chloroheterocyclic compounds in methanol and in ...
Authentication of Coscinium fenestratum among the other Menispermaceae plants prescribed in Thai folk medicines

Watthanachaiyingcharoen R.; Komatsu K.; Zhu S.; Vajragupta O.; Leelamanit W. (2010)

In Ayurveda and Thai traditional medicines, material from Coscinium fenestratum is commonly prescribed as active ingredients with diverse therapeutic purposes. However, C. fenestratum is also a seriously endangered medicinal ...
Neuritogenic activity of bi-functional bis-tryptoline triazole

Jiaranaikulwanitch J.; Tadtong S.; Govitrapong P.; Fokin V.V.; Vajragupta O. (2017)

Alzheimer's disease (AD) is a common neurodegenerative disorder, one of the hallmarks of which is the deposition of aggregated β-amyloid peptides (Aβ40,42) as plaques in the brain. Oligomers of these peptides have been ...
Novel multifunctional ascorbic triazole derivatives for amyloidogenic pathway inhibition, anti-inflammation, and neuroprotection

Jiaranaikulwanitch J.; Pandith H.; Tadtong S.; Thammarat P.; Jiranusornkul S.; Chauthong N.; Nilkosol S.; Vajragupta O. (2021)

Alzheimer’s disease (AD) is a common neurodegenerative disorder. The number of patients with AD is projected to reach 152 million by 2050. Donepezil, rivastigmine, galantamine, and memantine are the only four drugs currently ...
Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach

Sanphanya K.; Wattanapitayakul S.K.; Phowichit S.; Fokin V.V.; Vajragupta O. (2013)

We report a novel VEGFR-2 inhibitor, developed by the back-to-front approach. Docking experiments indicated that the 3-chloromethylphenylurea motif of the lead compound occupied the back pocket of VEGFR-2 kinase. An attempt ...
Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents

Sanphanya K.; Wattanapitayakul S.K.; Prangsaengtong O.; Jo M.; Koizumi K.; Shibahara N.; Priprem A.; Fokin V.V.; Vajragupta O. (2012)

Novel urea derivatives of alkynes have been designed, synthesized, and evaluated as potential cancer therapeutics leads. The most active 1-((3-chloromethyl)phenyl)-3-prop-2-ynylurea (1) exhibited cytotoxic effect against ...

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