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Browsing by Author "Failla M.L."

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Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites

Chitchumroonchokchai C.; Thomas-Ahner J.M.; Li J.; Riedl K.M.; Nontakham J.; Suksumrarn S.; Clinton S.K.; Kinghorn A.D.; Failla M.L. (2013)

Scope: This study investigated the in vivo and in vitro activity of α-mangostin (α-MG), the most abundant xanthone in mangosteen pericarp, on HT-29 cell tumorigenicity, proliferation, and several markers of tumor cell ...
Bioaccessibility, biotransformation, and transport of α-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells

Bumrungpert A.; Kalpravidh R.W.; Suksamrarn S.; Chaivisuthangkura A.; Chitchumroonchokchai C.; Failla M.L. (2009)

α- and γ- Mangostin are the most abundant prenylated xanthones present in the fruit of the mangosteen tree. These compounds have been reported to possess numerous bioactivities that have provided the impetus for use of ...
Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice

Gutierrez-Orozco F.; Thomas-Ahner J.M.; Berman-Booty L.D.; Galley J.D.; Chitchumroonchokchai C.; Mace T.; Suksamrarn S.; Bailey M.T.; Clinton S.K.; Lesinski G.B.; Failla M.L. (2014)

Scope: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. α-Mangostin (α-MG), the most abundant xanthone in mangosteen fruit, exerts anti-inflammatory and antibacterial activities in vitro. We evaluated ...
Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults

Chitchumroonchokchai C.; Riedl K.M.; Suksumrarn S.; Clinton S.K.; Kinghorn A.D.; Failla M.L. (2012)

The proposed health-promoting effects of the pericarp from mangosteen fruit have been attributed to a family of polyphenols referred to as xanthones. The purpose of this study was to determine the bioavailability of xanthones ...
α-Mangostin: Anti-inflammatory activity and metabolism by human cells

Gutierrez-Orozco F.; Chitchumroonchokchai C.; Lesinski G.B.; Suksamrarn S.; Failla M.L. (2013)

Information about the anti-inflammatory activity and metabolism of α-mangostin (α-MG), the most abundant xanthone in mangosteen fruit, in human cells is limited. On the basis of available literature, we hypothesized that ...

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