Please use this identifier to cite or link to this item:
https://ir.swu.ac.th/jspui/handle/123456789/15381| Title: | Study of genotoxic effects of antidiarrheal medicinal herbs on human cells in vitro. |
| Authors: | Settheetham W. Ishida T. |
| Keywords: | antidiarrheal agent DNA mutagenic agent plant extract angiosperm article Burkitt lymphoma cell culture cell division cell line cell survival Chinese medicine chromosome aberration comparative study drug effect fruit human medicinal plant mutagen testing phytotherapy Angiosperms Antidiarrheals Burkitt Lymphoma Cell Division Cell Line Cell Survival Chromosome Aberrations DNA, Neoplasm Fruit Humans Medicine, Chinese Traditional Mutagenicity Tests Mutagens Phytotherapy Plant Extracts Plants, Medicinal Tumor Cells, Cultured |
| Issue Date: | 1995 |
| Abstract: | The use of medicinal herbs has been a common practice in Asia but their genotoxic properties are little known. In the present study, genotoxic effects of three antidiarrheal herbs, guava leaf, mangosteen peel and pomegranate peel, were examined using established human cell lines, Raji and P3HR-1. Cells were treated with boiled-water extract of the herbs at various concentrations for 24 and 48 hours in vitro. Cell growth and viability were dose dependently reduced. No apparent chromosomal aberrations were induced by the treatment. Administration of pomegranate extract induced apoptotic DNA fragmentation. This genotoxicity test system is simple and convenient for the primary screening. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/15381 https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029442359&partnerID=40&md5=867743ecf393d1b379524c52e9e8fce6 |
| ISSN: | 1251562 |
| Appears in Collections: | Scopus 1983-2021 |
Files in This Item:
There are no files associated with this item.
Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.