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Title: Barakol: A potential anxiolytic extracted from Cassia siamea
Authors: Thongsaard W.
Deachapunya C.
Pongsakorn S.
Boyd E.A.
Bennett G.W.
Marsden C.A.
Keywords: anxiolytic agent
Cassia extract
cassia siamea extract
plant extract
unclassified drug
animal experiment
controlled study
exploratory behavior
intraperitoneal drug administration
maze test
oral drug administration
priority journal
traditional medicine
tranquilizing activity
Senna siamea
Issue Date: 1996
Abstract: The behavioural effects of an extract of Cassia siamea, a plant used in Thai traditional medicine, and barakol, its active chemical, were studied on an elevated plus-maze compared with diazepam. An aqueous extract of C. siamea (1, 6, and 12 g/kg body wt., orally) produced a small increase in the percentage of the open : total number of arm entries and time, time spent on the end of the open arms, total number of arm entries, and number of rears/min. Barakol [10 mg/kg, intraperitoneally (IP)] significantly increased all of these behavioural parameters in a manner similar to diazepam (1 mg/kg, IF, 30 or 60 min before testing), except that barakol and not diazepam increased both the number of rears and total arm entries. Barakol at 25 and 50 mg/kg increased the percentage of the open : total number of arm entries and time and number of rears. The results indicate that barakol has anxiolytic properties similar to diazepam but differs from diazepam in that it also increases exploratory and locomotor behaviour, as shown by the number of rears and total arm entries.
ISSN: 913057
Appears in Collections:SCOPUS 1983-2021

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