Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15358
Title: Barakol, a natural anxiolytic inhibits striatal dopamine release but not uptake in vitro
Authors: Thongsaard W.
Pongsakorn S.
Sudsuang R.
Bennett G.W.
Kendall D.A.
Marsden C.A.
Keywords: barakol
dopamine receptor stimulating agent
eticlopride
pergolide mesilate
quinelorane
unclassified drug
animal tissue
article
brain slice
controlled study
dopamine release
dopamine uptake
male
nonhuman
priority journal
rat
Animals
Anti-Anxiety Agents
Benzopyrans
Calcium
Cassia
Chromatography, High Pressure Liquid
Dopamine
Dopamine Agonists
Electrochemistry
Male
Neostriatum
Pergolide
Phenalenes
Plant Extracts
Plants, Medicinal
Potassium
Rats
Receptors, Dopamine D2
Issue Date: 1997
Abstract: The present study investigated the effects of barakol on the in vitro release of endogenous and radiolabelled dopamine from rat striatal slices in comparison with the dopamine receptor agonist, quinelorane dihydrochloride (1 μM) and pergolide methanesulfonate (100 μM), and the dopamine receptor antagonist, S(-)-eticlopride hydrochloride (10 μM) using a semi-superfusion method and high-performance liquid chromatography with electrochemical detector measurement of endogenous dopamine. Barakol (1, 10 and 100 μM) reduced K+-stimulated endogenous dopamine release as did the dopamine D2 receptor agonists but had no effect on [3H]dopamine release. The inhibition of barakol (10 μM) on K+-stimulated endogenous dopamine release was antagonised by a dopamine D2 receptor antagonist, eticlopride. Barakol (0.1 nM-10 μM) had no effect on [3H]dopamine uptake except at the highest concentration (100 μM) when inhibition was observed. The results indicate that barakol might act as a dopamine agonist to inhibit endogenous dopamine release without a change in dopamine uptake.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031032513&doi=10.1016%2fS0014-2999%2896%2900850-3&partnerID=40&md5=d480b100d07b0a8ee03d63404f839661
http://ir.swu.ac.th/jspui/handle/123456789/15358
ISSN: 142999
Appears in Collections:SCOPUS 1983-2021

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