Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15301
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dc.contributor.authorWattanasirichaigoon S.
dc.contributor.authorGordon F.D.
dc.contributor.authorResnick R.H.
dc.date.accessioned2021-04-05T04:33:28Z-
dc.date.available2021-04-05T04:33:28Z-
dc.date.issued2000
dc.identifier.issn3069877
dc.identifier.other2-s2.0-0033868262
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0033868262&doi=10.1054%2fmehy.1999.1034&partnerID=40&md5=0e05cadc9fadf30096648327b36398f0
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/15301-
dc.description.abstractComplications of portal hypertension remain perplexing physiologic phenomena in the understanding of shunt hemodynamics with multiple theories. Hyperdynamic circulation was also found in sepsis, chronic anemia and arterio-venous (A-V) fistula which relate to an increase in nitric oxide. We hypothesize that portosystemic collaterals may mimic an A-V fistula in which the high-pressure portal blood connects with the lower pressure systemic venous circulation. Although these collaterals decompress the portal circulation, a number of secondary hemodynamic phenomena occur which increase portal blood flow and tend to counteract the portal hypotensive effect of the portosystemic shunt. The consequent increases in cardiac output and portal blood flow perfuse the compromised liver. As portal blood flow increases, collateral flow increases and is nearly totally shunted in the systemic circulation. This shunt may eventually introduce a vicious cycle of hyperdynamic circulation into a compromised host. Ultimately, high-output cardiac failure occurs, leading to cirrhotic cardiomyopathy. (C) 2000 Harcourt Publishers Ltd.
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectnitric oxide synthase inhibitor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcardiomyopathy
dc.subjectcontrolled study
dc.subjectheart output
dc.subjecthemodynamics
dc.subjectnonhuman
dc.subjectportal hypertension
dc.subjectportal vein blood flow
dc.subjectpriority journal
dc.subjectrat
dc.subjectAnimalia
dc.subjectFistula
dc.titleHyperdynamic circulation in portal hypertension: A comparative model of arterio-venous fistula
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationMedical Hypotheses. Vol 55, No.1 (2000), p.77-87
dc.identifier.doi10.1054/mehy.1999.1034
Appears in Collections:Scopus 1983-2021

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