Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15151
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChanyachukul T.
dc.contributor.authorYoovathaworn K.
dc.contributor.authorThongsaard W.
dc.contributor.authorChongthammakun S.
dc.contributor.authorNavasumrit P.
dc.contributor.authorSatayavivad J.
dc.date.accessioned2021-04-05T04:32:46Z-
dc.date.available2021-04-05T04:32:46Z-
dc.date.issued2004
dc.identifier.issn3784274
dc.identifier.other2-s2.0-1942517470
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-1942517470&doi=10.1016%2fj.toxlet.2004.02.007&partnerID=40&md5=7d1aa4f9db97d0ed7d077b19a225c6ca
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/15151-
dc.description.abstractAlterations of motor behavioral patterns and monoamine contents in the discrete rat brain areas after acute paraquat exposure (3, 5, 10, 20mg/kg, s.c.) have been studied. The results showed that paraquat at the doses of 5, 10, and 20mg/kg significantly reduced locomotive, stereotypic, and rotational behaviors. Significant decreases of norepinephrine (NE) contents in cortex and hypothalamus, as well as striatal contents of dopamine (DA) and its acidic metabolites, were detected. In addition, L-valine (200mg/kg, i.p.) significantly attenuated paraquat-induced toxicity at moderate dose (5mg/kg) but not at high dose (20mg/kg). The results provide evidence that paraquat can enter the brain as illustrated by the alterations in the motor behavioral pattern and neurochemical contents. Furthermore, the attenuation effect of L-valine against systemic administration of paraquat-induced motor behaviors was detected, with a slightly protective effect on paraquat-induced neurochemical alterations. © 2004 Elsevier Ireland Ltd. All rights reserved.
dc.subjectdopamine
dc.subjectmonoamine
dc.subjectnoradrenalin
dc.subjectparaquat
dc.subjectvaline
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectattenuation
dc.subjectbrain cortex
dc.subjectbrain level
dc.subjectcontrolled study
dc.subjectdopamine brain level
dc.subjectdose response
dc.subjectdrug effect
dc.subjecthypothalamus
dc.subjectlocomotion
dc.subjectmale
dc.subjectmetabolite
dc.subjectmotor dysfunction
dc.subjectneurochemistry
dc.subjectneurotoxicity
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectstereotypy
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectBrain
dc.subjectDopamine
dc.subjectDose-Response Relationship, Drug
dc.subjectHerbicides
dc.subjectInjections, Intraperitoneal
dc.subjectInjections, Subcutaneous
dc.subjectMale
dc.subjectMotor Activity
dc.subjectNorepinephrine
dc.subjectParaquat
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectValine
dc.titleAttenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationToxicology Letters. Vol 150, No.3 (2004), p.259-269
dc.identifier.doi10.1016/j.toxlet.2004.02.007
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.