Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15135
Title: Influence of selected surfactants on the tackiness of acrylic polymer films
Authors: Nimkulrat S.
Suchiva K.
Phinyocheep P.
Puttipipatkhachorn S.
Keywords: acrylic acid derivative
eudragit
glycerol stearate
lactose
microcrystalline cellulose
polymer
povidone
sorbitan ester
sorbitan oleate
sorbitan palmitate
sorbitan stearate
surfactant
talc
theophylline
article
chemical composition
film
infrared spectroscopy
microscopy
priority journal
reflectometry
surface property
Polymethacrylic Acids
Solubility
Surface-Active Agents
Issue Date: 2004
Abstract: Anti-tacking agents are always necessary in polymeric film coating formulations in order to prevent substrate agglomeration. The objective of this study was to investigate the abilities of certain nonionic surfactants in a group of sorbitan ester in reducing the tackiness of the films obtained from aqueous acrylic polymer dispersions (Eudragit ®), compared with those of talc and glyceryl monostearate (GMS). The results from the peel tests demonstrated that GMS, Span 60 and Span 40 could significantly reduce the tackiness of both Eudragit NE 30D and Eudragit RS 30D films. The mechanisms in reducing the film tackiness were investigated by analyzing the film compositions, using attenuated total internal reflectance infrared spectroscopy (ATR-IR) and optical microscopy. The storage modulus of the films was also examined. The results indicated that GMS, Span 60, and Span 40 could reduce the film tackiness by decreasing the polymer contents at the film surfaces, resulting in a notable reduction in the contact area of the polymers between the surfaces. The use of only 5% (w/w) of either GMS, Span 60 or Span 40 in the coating formulations is enough to prevent pellet agglomeration without adverse effects on film flexibility. The pellets coated with Eudragit RS 30D/RL 30D (9:1, w/w) did not exhibit any difference in the drug release profiles when either 100% (w/w) talc or 5% (w/w) GMS was used, whereas the formulations containing Span 60 or Span 40 gave a slightly faster release rate. © 2004 Elsevier B.V. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-8444238561&doi=10.1016%2fj.ijpharm.2004.08.022&partnerID=40&md5=a0de012be71b15d1099455c9350dc5f6
http://ir.swu.ac.th/jspui/handle/123456789/15135
ISSN: 3785173
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.