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Title: Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities
Authors: Suksrichavalit T.
Prachayasittikul S.
Nantasenamat C.
Isarankura-Na-Ayudhya C.
Prachayasittikul V.
Keywords: 2 aminopyridine
copper complex
nicotinic acid
nicotinic acid 2 aminopyridine copper complex
nicotinic acid 2 hydroxypyridine copper complex
nicotinic acid picolinic acid copper complex
picolinic acid
pyridine derivative
reactive oxygen metabolite
superoxide dismutase
unclassified drug
Aeromonas hydrophila
antimicrobial activity
antioxidant activity
Bacillus cereus
Bacillus subtilis
Candida albicans
Citrobacter freundii
density functional theory
drug synthesis
enzyme activity
IC 50
infrared spectroscopy
Listeria monocytogenes
minimum inhibitory concentration
molecular model
Morganella morganii
Plesiomonas shigelloides
quantum chemistry
Salmonella enteritidis
Shigella dysenteriae
Streptococcus pyogenes
Anti-Infective Agents
Free Radical Scavengers
Inhibitory Concentration 50
Models, Molecular
Molecular Conformation
Organometallic Compounds
Quantum Theory
Spectrophotometry, Infrared
Superoxide Dismutase
Issue Date: 2009
Abstract: Superoxide anions are reactive oxygen species that can attack biomolecules such as DNA, lipids and proteins to cause many serious diseases. This study reports the synthesis of copper complexes of nicotinic acid with related pyridine derivatives. The copper complexes were shown to possess superoxide dismutase (SOD) and antimicrobial activities. The copper complexes exerted SOD activity in range of 49.07-130.23 μM. Particularly, copper complex of nicotinic acid with 2-hydroxypyridine was the most potent SOD mimic with an IC50 of 49.07 μM. In addition, the complexes exhibited antimicrobial activity against Bacillus subtilis ATCC 6633 and Candida albicans ATCC 90028 with MIC range of 128-256 μg/mL. The SOD activities were well correlated with the theoretical parameters as calculated by density functional theory at the B3LYP/LANL2DZ level of theory. Interestingly, the SOD activity of the copper complexes was demonstrated to be inversely correlated with the electron affinity, but was well correlated with both HOMO and LUMO energies. The vitamin-metal complexes described in this report are great examples of the value-added benefits of vitamins for medicinal applications. © 2009 Elsevier Masson SAS. All rights reserved.
ISSN: 2235234
Appears in Collections:SCOPUS 1983-2021

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