Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15030
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dc.contributor.authorTripanichkul W.
dc.contributor.authorSripanichkulchai K.
dc.contributor.authorFinkelstein D.I.
dc.date.accessioned2021-04-05T04:32:22Z-
dc.date.available2021-04-05T04:32:22Z-
dc.date.issued2006
dc.identifier.issn68993
dc.identifier.other2-s2.0-33646388397
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33646388397&doi=10.1016%2fj.brainres.2006.02.029&partnerID=40&md5=5c0a295fc660ce656359267fbace76bb
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/15030-
dc.description.abstractEmerging evidence suggests beneficial effect of estrogen for Parkinson's disease (PD), yet the exact mechanisms implicated remain obscured. Activated glia observed in MPTP mouse model and in PD may participate in the cascade of deleterious events that ultimately leads to dopaminergic nigral neuronal death. In vitro studies demonstrate that estrogen can modify the microglial and astroglial expression of inflammatory mediator, such as cytokines and chemokines implicated in neuroinflammation and neurodegeneration. To determine whether estrogen-elicited neuroprotection in PD is mediated through glia, adult male C57Bl/6 mice were treated with 17β-estradiol (E2) for a total of 11 days. Following 5 days of pretreatment with E2, they were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the sixth day. The brains were collected on day 11. Immunohistochemistry and quantitative study were used to assess the number of tyrosine hydroxylase-immunoreactive (TH-IR) neurons in the substantia nigra pars compacta (SNpc) and that of activated astrocytes and activated microglia in the SNpc and the striatum. Pretreatment with E2 decreased the loss of TH-IR nigral neurons and diminished the deficit of TH-IR striatal fibers triggered by MPTP. The neuroprotective effect of E2 was coincident with an attenuation of a glial response within the nigra and the striatum. These findings suggest that the neuroprotective effects of E2 evidenced in MPTP mouse model might mediate through an inhibition of reactive glia. However, direct neuroprotective effects of E2 upon TH-IR neurons cannot be excluded. © 2006 Elsevier B.V. All rights reserved.
dc.subject1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine
dc.subjectestradiol
dc.subjectestrogen
dc.subjecttyrosine 3 monooxygenase
dc.subjectanimal cell
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectastrocyte
dc.subjectcell activation
dc.subjectcell loss
dc.subjectcontrolled study
dc.subjectcorpus striatum
dc.subjectdisease model
dc.subjectdown regulation
dc.subjectglia cell
dc.subjectimmunocompetent cell
dc.subjectimmunohistochemistry
dc.subjectinjection
dc.subjectmale
dc.subjectmouse
dc.subjectnerve cell
dc.subjectnerve fiber
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectpriority journal
dc.subjectquantitative analysis
dc.subjectsubstantia nigra
dc.subject1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBasal Ganglia
dc.subjectCell Count
dc.subjectCell Death
dc.subjectDisease Models, Animal
dc.subjectDrug Administration Schedule
dc.subjectEstrogens
dc.subjectGene Expression Regulation
dc.subjectGlial Fibrillary Acidic Protein
dc.subjectImmunohistochemistry
dc.subjectLectins
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectNeuroglia
dc.subjectNeurons
dc.subjectNeurotoxicity Syndromes
dc.subjectTyrosine 3-Monooxygenase
dc.subjectAnimalia
dc.titleEstrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationBrain Research. Vol 1084, No.1 (2006), p.28-37
dc.identifier.doi10.1016/j.brainres.2006.02.029
Appears in Collections:Scopus 1983-2021

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