Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15023
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dc.contributor.authorTrisomboon H.
dc.contributor.authorMalaivijitnond S.
dc.contributor.authorWatanabe G.
dc.contributor.authorCherdshewasart W.
dc.contributor.authorTaya K.
dc.date.accessioned2021-04-05T04:32:21Z-
dc.date.available2021-04-05T04:32:21Z-
dc.date.issued2006
dc.identifier.issn1355008X
dc.identifier.other2-s2.0-33646861393
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33646861393&doi=10.1385%2fENDO%3a29%3a1%3a129&partnerID=40&md5=da082d9a17f0962f223720b3d5c4cc9e
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/15023-
dc.description.abstractWe investigated the effect of Pueraria mirifica (PM) on gonadotrophin and estradiol levels in aged animals; nine menopausal cynomolgus monkeys were divided into three groups. Each group (n = 3) was fed with 10, 100, and 1000 mg/d of PM for 90 d. PM-10 induced the decrease of follicle stimulating hormone (FSH) levels on d 15-90 in one out of three monkeys. PM-100 and PM-1000 decreased FSH levels of all monkeys throughout the treatment period. After the treatment period, FSH levels continued to decrease for 5 and 10-20 d in PM-100 and PM-1000, respectively, and the levels rebounded in all groups thereafter. PM-10 decreased luteinizing hormone (LH) levels throughout the treatment period in one out of three monkeys and returned to the pretreatment levels immediately after stopping treatment. PM-100 and PM-1000 prominently decreased LH levels between d 10 and 90 during treatment and persisted until d 15-25 and d 20-30 for PM-100 and PM-1000, respectively, during the post-treatment period. Serum LH levels rebounded after returning to pre-treatment levels in a dose-dependent manner. Estradiol levels tended to decrease during the treatment period in all groups. The daily feeding of PM suppressed gonadotrophin levels in aged menopausal monkeys based on dose. Moreover, they can be recovered, and there is a direct correlation between dosage and recovery time. PM may be effective as an alternative medicine in menopausal women because the effects are not permanent. © 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.
dc.subjectestradiol
dc.subjectfollitropin
dc.subjectgonadotropin
dc.subjectherbaceous agent
dc.subjectluteinizing hormone
dc.subjectpueraria mirifica extract
dc.subjectunclassified drug
dc.subjectaged
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectdose response
dc.subjectestradiol blood level
dc.subjectfemale
dc.subjectfollitropin blood level
dc.subjectgonadotropin blood level
dc.subjectluteinizing hormone blood level
dc.subjectmenopause
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectPueraria
dc.subjectpueraria mirifica
dc.subjectAging
dc.subjectAnimals
dc.subjectDose-Response Relationship, Drug
dc.subjectEstradiol
dc.subjectFemale
dc.subjectFollicle Stimulating Hormone
dc.subjectGonadotropins
dc.subjectLuteinizing Hormone
dc.subjectMacaca fascicularis
dc.subjectMenopause
dc.subjectPhytotherapy
dc.subjectPlant Preparations
dc.subjectPueraria
dc.subjectRadioimmunoassay
dc.titleThe estrogenic effect of Pueraria mirifica on gonadotrophin levels in aged monkeys
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationEndocrine. Vol 29, No.1 (2006), p.129-134
dc.identifier.doi10.1385/ENDO:29:1:129
Appears in Collections:Scopus 1983-2021

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