Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15012
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dc.contributor.authorJaroenporn S.
dc.contributor.authorMalaivijitnond S.
dc.contributor.authorWattanasirmkit K.
dc.contributor.authorTrisomboon H.
dc.contributor.authorWatanabe G.
dc.contributor.authorTaya K.
dc.contributor.authorCherdshewasart W.
dc.date.accessioned2021-04-05T04:32:20Z-
dc.date.available2021-04-05T04:32:20Z-
dc.date.issued2006
dc.identifier.issn1355008X
dc.identifier.other2-s2.0-33845870129
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33845870129&doi=10.1385%2fENDO%3a30%3a1%3a93&partnerID=40&md5=df9e4d41f7aaf57900d74e3c055a6983
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/15012-
dc.description.abstractThe effects of Pueraria mirifica (PM) on reproductive organs and fertility of adult male mice were investigated. Male mice were divided into four groups (10 mice/group). Groups 1-3 were orally treated with PM at doses of 0 (PM-0), 10 (PM-10), and 100 (PM-100) mg/kg BW/d in 0.2 mL distilled water, and group 4 was subcutaneously injected with 200 μg/kg BW/d of synthetic estrogen diesthylstilbestol (DES). The treatment schedule was separated into two periods: treatment and posttreatment (8 wk for each period). The PM-10 and PM-100 treatments had no effect on testicular weight, sperm number, and serum LH, FSH, and testosterone levels. Only the PM-100 treatment reduced weights of epididymes and seminal vesicle and the sperm motility and viability. Histopathological examination demonstrated that testis, epididymis, and seminal vesicle were normal in all doses of PM treatment. PM-treated males showed no alterations in mating efficiency and on causing pregnancy of their female partners. DES injection impaired all those parameters. Offspring fathered by the PM- and DES-treated males exhibited neither malformations nor change of body weight gains, and the reproductive organ weights of 50-d old pups were in the normal range. The present data clearly demonstrate that a long-term treatment of PM at doses 10 and 100 mg/kg BW/d, via oral route, does not alter a male fertility and a hypothalamus- pituitary-testis axis. Although PM-100 can cause some moderate impairment, no persistent effects were observed. Most of PM-treated mice increased the mating efficiency after stop treatment. © 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.
dc.subjectdiethylstilbestrol
dc.subjectfollitropin
dc.subjectherbaceous agent
dc.subjectluteinizing hormone
dc.subjectphytoestrogen
dc.subjecttestosterone
dc.subjectwater
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectepididymis
dc.subjectfemale
dc.subjectgenital system
dc.subjecthistopathology
dc.subjecthypophysis testis system
dc.subjecthypothalamus hypophysis system
dc.subjectlong term care
dc.subjectluteinizing hormone blood level
dc.subjectmale
dc.subjectmale fertility
dc.subjectmating
dc.subjectmouse
dc.subjectnonhuman
dc.subjectorgan weight
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectprogeny
dc.subjectPueraria
dc.subjectPueraria mirifica
dc.subjectseminal vesicle
dc.subjectsexual behavior
dc.subjectspermatozoon count
dc.subjectspermatozoon motility
dc.subjecttestis
dc.subjecttestis weight
dc.subjecttestosterone blood level
dc.subjectAnimals
dc.subjectDiethylstilbestrol
dc.subjectEpididymis
dc.subjectFemale
dc.subjectFertility
dc.subjectFollicle Stimulating Hormone
dc.subjectGenitalia, Male
dc.subjectHistocytochemistry
dc.subjectLuteinizing Hormone
dc.subjectMale
dc.subjectMice
dc.subjectOrgan Size
dc.subjectPhytoestrogens
dc.subjectPregnancy
dc.subjectPueraria
dc.subjectSeminal Vesicles
dc.subjectSperm Count
dc.subjectSperm Motility
dc.subjectTestis
dc.subjectTestosterone
dc.titleEffects of Pueraria mirifica, an herb containing phytoestrogens, on reproductive organs and fertility of adult male mice
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationEndocrine. Vol 30, No.1 (2006), p.93-101
dc.identifier.doi10.1385/ENDO:30:1:93
Appears in Collections:Scopus 1983-2021

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