Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14951
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dc.contributor.authorTrisomboon H.
dc.contributor.authorMalaivijitnond S.
dc.contributor.authorCherdshewasart W.
dc.contributor.authorWatanabe G.
dc.contributor.authorTaya K.
dc.date.accessioned2021-04-05T04:32:12Z-
dc.date.available2021-04-05T04:32:12Z-
dc.date.issued2007
dc.identifier.issn9168818
dc.identifier.other2-s2.0-34248365681
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34248365681&doi=10.1262%2fjrd.18079&partnerID=40&md5=99dac997318bded9fe9ecf85238b4eda
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/14951-
dc.description.abstractThis study investigated the changes in the urinary hormone levels of female monkeys (Macaca fascicularis) after single-dose and long-term treatments with Pueraria mirifica (PM). The monkeys were separated into 3 groups (n=3) and orally treated with 10, 100, or 1,000 mg of PM in each group. Two series of experiments were performed. In the first series of experiments, the monkeys were orally treated with a single dose of PM. The experimental schedule was divided into a one menstrual cycle pretreatment period and a two menstrual cycle post-treatment period. In the second series of experiments, the monkeys were orally treated daily with PM for 90 days. The experiment schedule was divided into a one menstrual cycle pretreatment period, a three menstrual cycle treatment period, and a two menstrual cycle post-treatment period. Urinary samples were collected daily and assayed for the FSH, LH, estradiol, and progesterone levels. The results showed that there were no changes in the FSH, LH, estradiol, and progesterone levels after treatment with a single dose of 10, 100, or 1,000 mg of PM or after daily treatment with 10 mg of PM for 90 days compared with the levels observed during the pretreatment period. Daily treatment with 100 mg and 1,000 mg of PM for 90 days only produced a clear reduction in the urinary FSH levels. This suggests that changes of urinary FSH levels can be considered an indicator for study of estrogenic effects on hormonal levels in female monkeys.
dc.subjectestradiol
dc.subjectgonadotropin
dc.subjecthormone
dc.subjectphytoestrogen
dc.subjectprogesterone
dc.subjectsteroid
dc.subjectanimal
dc.subjectarticle
dc.subjectfemale
dc.subjectherbal medicine
dc.subjectMacaca
dc.subjectmenstrual cycle
dc.subjectPueraria
dc.subjecturine
dc.subjectAnimals
dc.subjectEstradiol
dc.subjectFemale
dc.subjectGonadotropins
dc.subjectHormones
dc.subjectMacaca fascicularis
dc.subjectMedicine, Herbal
dc.subjectMenstrual Cycle
dc.subjectPhytoestrogens
dc.subjectProgesterone
dc.subjectPueraria
dc.subjectSteroids
dc.subjectMacaca
dc.subjectMacaca fascicularis
dc.subjectPueraria
dc.subjectPueraria mirifica
dc.titleAssessment of urinary gonadotropin and steroid hormone profiles of female cynomolgus monkeys after treatment with Pueraria mirifica
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Reproduction and Development. Vol 53, No.2 (2007), p.395-403
dc.identifier.doi10.1262/jrd.18079
Appears in Collections:Scopus 1983-2021

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