Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14903
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChang P.-L.
dc.contributor.authorHarkins L.
dc.contributor.authorHsieh Y.-H.
dc.contributor.authorHicks P.
dc.contributor.authorSappayatosok K.
dc.contributor.authorYodsanga S.
dc.contributor.authorSwasdison S.
dc.contributor.authorChambers A.F.
dc.contributor.authorElmets C.A.
dc.contributor.authorHo K.-J.
dc.date.accessioned2021-04-05T04:32:05Z-
dc.date.available2021-04-05T04:32:05Z-
dc.date.issued2008
dc.identifier.issn221554
dc.identifier.other2-s2.0-37249014473
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-37249014473&doi=10.1369%2fjhc.7A7325.2007&partnerID=40&md5=fb7a39a8b70dd970d6da73b6903cfb68
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/14903-
dc.description.abstractOsteopontin (OPN) is an adhesive, matricellular glycoprotein, whose expression is elevated in many types of cancer and has been shown to facilitate tumorigenesis in vivo. To understand the role of OPN in human skin cancer, this study is designed to determine whether OPN is expressed in premalignant [solar/actinic keratosis (AK)] and in malignant skin lesions such as squamous cell carcinomas (SCC) and basal cell carcinomas (BCC), as well as in normal skin exposed or not exposed to sunlight. Immunohistochemical analyses showed that OPN is expressed in SCC (20/20 cases) and in AK (16/16 cases), which are precursors to SCC, but is absent or minimally expressed in solid BCC (17 cases). However, positive staining for OPN was observed in those BCC that manifest differentiation toward epidermal appendages such as keratotic BCC. In sunlight-exposed normal skin, OPN is minimally expressed in the basal cell layer, but in contrast to those not exposed to sunlight, OPN is more prominent in the spinous cell layer with increasing intensity toward the granular cell layer. Additionally, OPN is expressed in the hair follicles, sebaceous glands, and sweat glands of normal skin. In conclusion, these data suggest that OPN is associated with keratinocyte differentiation and that it is expressed in AK and SCC, which have metastatic potential, but minimally expressed in solid BCC. © The Histochemical Society, Inc.
dc.subjectosteopontin
dc.subjectarticle
dc.subjectbasal cell
dc.subjectbasal cell carcinoma
dc.subjectcell differentiation
dc.subjectcontrolled study
dc.subjectgranular cell
dc.subjecthair follicle
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectkeratinocyte
dc.subjectmale
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectsebaceous gland
dc.subjectskin
dc.subjectskin cancer
dc.subjectsquamous cell carcinoma
dc.subjectsun exposure
dc.subjectsweat gland
dc.subjectCarcinoma, Basal Cell
dc.subjectCarcinoma, Squamous Cell
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKeratosis
dc.subjectOsteopontin
dc.subjectPhotosensitivity Disorders
dc.subjectPrecancerous Conditions
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectSkin
dc.subjectSkin Neoplasms
dc.subjectSunlight
dc.titleOsteopontin expression in normal skin and non-melanoma skin tumors
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Histochemistry and Cytochemistry. Vol 56, No.1 (2008), p.57-66
dc.identifier.doi10.1369/jhc.7A7325.2007
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.