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Title: Osteopontin expression in normal skin and non-melanoma skin tumors
Authors: Chang P.-L.
Harkins L.
Hsieh Y.-H.
Hicks P.
Sappayatosok K.
Yodsanga S.
Swasdison S.
Chambers A.F.
Elmets C.A.
Ho K.-J.
Keywords: osteopontin
basal cell
basal cell carcinoma
cell differentiation
controlled study
granular cell
hair follicle
human tissue
priority journal
protein expression
sebaceous gland
skin cancer
squamous cell carcinoma
sun exposure
sweat gland
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Photosensitivity Disorders
Precancerous Conditions
Reverse Transcriptase Polymerase Chain Reaction
Skin Neoplasms
Issue Date: 2008
Abstract: Osteopontin (OPN) is an adhesive, matricellular glycoprotein, whose expression is elevated in many types of cancer and has been shown to facilitate tumorigenesis in vivo. To understand the role of OPN in human skin cancer, this study is designed to determine whether OPN is expressed in premalignant [solar/actinic keratosis (AK)] and in malignant skin lesions such as squamous cell carcinomas (SCC) and basal cell carcinomas (BCC), as well as in normal skin exposed or not exposed to sunlight. Immunohistochemical analyses showed that OPN is expressed in SCC (20/20 cases) and in AK (16/16 cases), which are precursors to SCC, but is absent or minimally expressed in solid BCC (17 cases). However, positive staining for OPN was observed in those BCC that manifest differentiation toward epidermal appendages such as keratotic BCC. In sunlight-exposed normal skin, OPN is minimally expressed in the basal cell layer, but in contrast to those not exposed to sunlight, OPN is more prominent in the spinous cell layer with increasing intensity toward the granular cell layer. Additionally, OPN is expressed in the hair follicles, sebaceous glands, and sweat glands of normal skin. In conclusion, these data suggest that OPN is associated with keratinocyte differentiation and that it is expressed in AK and SCC, which have metastatic potential, but minimally expressed in solid BCC. © The Histochemical Society, Inc.
ISSN: 221554
Appears in Collections:Scopus 1983-2021

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