Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14843
Title: Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.
Authors: Prachayasittikul S.
Manam P.
Chinworrungsee M.
Isarankura-Na-ayudhya C.
Ruchirawat S.
Prachayasittikul V.
Keywords: alkaloid
antiinfective agent
antimalarial agent
flavanone derivative
onychine
plant extract
pyridone derivative
sitosterol
sitosterol derivative
stigmasterol
triterpene
article
cell line
cell survival
chemical structure
chemistry
drug effect
human
microbiological examination
Plasmodium falciparum
Polyalthia
tumor cell line
Alkaloids
Anti-Infective Agents
Antimalarials
Cell Line
Cell Line, Tumor
Cell Survival
Flavanones
Humans
Microbial Sensitivity Tests
Molecular Structure
Plant Extracts
Plasmodium falciparum
Polyalthia
Pyridones
Sitosterols
Stigmasterol
Triterpenes
Issue Date: 2009
Abstract: This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-73349142009&doi=10.3390%2fmolecules14114414&partnerID=40&md5=0dafd56146fb6c95cc791de3be2ea54c
http://ir.swu.ac.th/jspui/handle/123456789/14843
ISSN: 14203049
Appears in Collections:SCOPUS 1983-2021

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