Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14782
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dc.contributor.authorPhawong C.
dc.contributor.authorOuma C.
dc.contributor.authorTangteerawatana P.
dc.contributor.authorThongshoob J.
dc.contributor.authorWere T.
dc.contributor.authorMahakunkijcharoen Y.
dc.contributor.authorWattanasirichaigoon D.
dc.contributor.authorPerkins D.J.
dc.contributor.authorKhusmith S.
dc.date.accessioned2021-04-05T03:37:14Z-
dc.date.available2021-04-05T03:37:14Z-
dc.date.issued2010
dc.identifier.issn937711
dc.identifier.other2-s2.0-77953153281
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77953153281&doi=10.1007%2fs00251-010-0439-y&partnerID=40&md5=64e0ad14305343afdee4d38f34c43d4b
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/14782-
dc.description.abstractPolymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning severe malaria in Thai adults is largely unexplored, the functional association between IL12B polymorphisms [i.e. IL12Bpro (rs17860508) and IL12B 3′ UTR T/G (rs3212227)], severe malaria and cytokine production was examined in patients with Plasmodium falciparum infections (n=355) recruited from malaria endemic areas along the Thai-Myanmar border in northwest Thailand. Circulating IL-12p40 (p=0.049) and IFN-γ (p=0.051) were elevated in patients with severe malaria, while only IL-12p40 was significantly higher in severe malaria patients with hyperparasitaemia (p=0.046). Carriage of the IL12Bpro1.1 genotype was associated with enhanced severity of malaria (OR, 2.34; 95% CI, 0.94-5.81; p=0.066) and hyperparasitaemia (OR, 3.42; 95% CI, 1.17-9.87; p=0.025) relative to the IL12Bpro2.2 genotype (wild type). Individuals with the IL12Bpro1.1 genotype also had the lowest IL-12p40 (p=0.002) and the highest IFN-γ (p=0.004) levels. Construction of haplotypes revealed that carriage of the IL12Bpro-2/3′ UTR-T haplotype was associated with protection against severe malaria (OR, 0.51; 95% CI, 0.29-0.90; p=0.020) and reduced circulating IFN-γ (p=0.06). Thus, genotypic and haplotypic variation at IL12Bpro and IL12B 3′ UTR in this population influences susceptibility to severe malaria and functional changes in circulating IL-12p40 and IFN-γ levels. Results presented here suggest that protection against severe malaria in Thai adults is associated with genotypic variants that condition enhanced IL-12p40 and reduced IFN-γ levels. © 2010 Springer-Verlag.
dc.subjectgamma interferon
dc.subjectinterleukin 12p40
dc.subjectgamma interferon
dc.subjectinterleukin 12
dc.subjectinterleukin 12p40
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcytokine production
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectDNA extraction
dc.subjectDNA polymorphism
dc.subjectenzyme linked immunosorbent assay
dc.subjectgene amplification
dc.subjectgenotype
dc.subjecthaplotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmalaria
dc.subjectnonhuman
dc.subjectparasitemia
dc.subjectPlasmodium falciparum
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectThailand
dc.subject3' untranslated region
dc.subjectadolescent
dc.subjectblood
dc.subjectfemale
dc.subjectgenetic polymorphism
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjecthaplotype
dc.subjectimmunology
dc.subjectmalaria falciparum
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpromoter region
dc.subjectPlasmodium falciparum
dc.subject3' Untranslated Regions
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectHaplotypes
dc.subjectHumans
dc.subjectInterferon-gamma
dc.subjectInterleukin-12
dc.subjectInterleukin-12 Subunit p40
dc.subjectMalaria, Falciparum
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectParasitemia
dc.subjectPolymorphism, Genetic
dc.subjectPromoter Regions, Genetic
dc.titleHaplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationImmunogenetics. Vol 62, No.6 (2010), p.345-356
dc.identifier.doi10.1007/s00251-010-0439-y
Appears in Collections:Scopus 1983-2021

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