Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14729
Title: Identification of ricinoleic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast
Authors: Attrapadung S.
Yoshida J.
Kimura K.-I.
Mizunuma M.
Miyakawa T.
Thanomsub B.W.
Keywords: calcium chloride
cyclin dependent kinase 1
fatty acid
fungal protein
protein Cln2p
protein Swe1p
ricinoleic acid
tyrosine
unclassified drug
article
calcium signaling
cell cycle G2 phase
cell cycle regulation
controlled study
enzyme phosphorylation
fungus growth
nonhuman
protein expression
yeast
Calcium Chloride
Calcium Signaling
CDC2-CDC28 Kinases
Cell Cycle
Cell Cycle Proteins
Cyclins
Growth Inhibitors
Phosphorylation
Protein-Tyrosine Kinases
Ricinoleic Acids
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Animalia
Eukaryota
Saccharomyces cerevisiae
Saccharomycetales
Issue Date: 2010
Abstract: Free fatty acids exhibit diverse biological effects such as the regulation of immune responses in humans and animals. To investigate the biological effect of fatty acids in the model eukaryotic organism yeast, we examined the activity of various fatty acids in a yeast-based drug-screening system designed to detect the small-molecule compounds that inhibit Ca2+-signal-mediated cell-cycle regulation. Among the fatty acids examined, ricinoleic acid markedly alleviated the deleterious physiological effects induced by the compelled activation of Ca2+ signaling by external CaCl2, such as the polarized bud growth and the growth arrest in the G2 phase. In accordance with the physiological consequences induced by ricinoleic acid, it diminished the Ca2+-induced phosphorylation of Cdc28p at Tyr-19, concomitant with the decrease in the Ca2+-stimulated expression levels of Cln2p and Swe1p. © 2009 Federation of European Microbiological Societies.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-74549196285&doi=10.1111%2fj.1567-1364.2009.00592.x&partnerID=40&md5=cd503d502a03643e8b184fa1555d3e4f
http://ir.swu.ac.th/jspui/handle/123456789/14729
ISSN: 15671356
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.