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Title: Identification of ricinoleic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast
Authors: Attrapadung S.
Yoshida J.
Kimura K.-I.
Mizunuma M.
Miyakawa T.
Thanomsub B.W.
Keywords: calcium chloride
cyclin dependent kinase 1
fatty acid
fungal protein
protein Cln2p
protein Swe1p
ricinoleic acid
unclassified drug
calcium signaling
cell cycle G2 phase
cell cycle regulation
controlled study
enzyme phosphorylation
fungus growth
protein expression
Calcium Chloride
Calcium Signaling
CDC2-CDC28 Kinases
Cell Cycle
Cell Cycle Proteins
Growth Inhibitors
Protein-Tyrosine Kinases
Ricinoleic Acids
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Saccharomyces cerevisiae
Issue Date: 2010
Abstract: Free fatty acids exhibit diverse biological effects such as the regulation of immune responses in humans and animals. To investigate the biological effect of fatty acids in the model eukaryotic organism yeast, we examined the activity of various fatty acids in a yeast-based drug-screening system designed to detect the small-molecule compounds that inhibit Ca2+-signal-mediated cell-cycle regulation. Among the fatty acids examined, ricinoleic acid markedly alleviated the deleterious physiological effects induced by the compelled activation of Ca2+ signaling by external CaCl2, such as the polarized bud growth and the growth arrest in the G2 phase. In accordance with the physiological consequences induced by ricinoleic acid, it diminished the Ca2+-induced phosphorylation of Cdc28p at Tyr-19, concomitant with the decrease in the Ca2+-stimulated expression levels of Cln2p and Swe1p. © 2009 Federation of European Microbiological Societies.
ISSN: 15671356
Appears in Collections:Scopus 1983-2021

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