Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14682
Title: Vasorelaxation and superoxide scavenging activities of orotic acid
Authors: Prachayasittikul S.
Wongsawatkul O.
Worachartcheewan A.
Ruchirawat S.
Prachayasittikul V.
Keywords: 1,1 diphenyl 2 picrylhydrazyl
acetylcholine
indometacin
n(g) nitroarginine methyl ester
nitric oxide
orotic acid
prostacyclin
superoxide dismutase
animal experiment
animal tissue
antioxidant activity
aorta constriction
article
controlled study
drug mechanism
drug potentiation
drug response
drug structure
endothelium cell
male
nonhuman
rat
thoracic aorta
vasodilatation
Issue Date: 2010
Abstract: The aim of study is to investigate effects of orotic acid (OA) on phenylephrine-induced contraction of rat thoracic aorta and its antioxidative activity. Results showed that the OA exhibited maximal vasorelaxation in dose-dependent manner with ED50 of 3.1?×10-7 M, but the effect was less than those of acetylcholine (ACh)-induced nitric oxide (NO) vasorelaxation. Significant reductions of the vasorelaxations were found in the presence of either NG-nitro-L-arginine methyl ester (L-NAME) or indomethacin (INDO). Synergistic effects were observed in the presence of L-NAME plus INDO that led to loss of vasorelaxation of both the ACh and the OA. In addition, complete loss of the vasorelaxation was manifested under removal of endothelial cells. This implies that the vasorelaxations are mediated by partially endothelium-induced NO and prostacyclin. The OA exhibited antioxidative activity in both DPPH and SOD assays. The significant results reveal novel actions of the OA as vasorelaxants and superoxide scavenger which are benefits as therapeutic uses and health supplements. © 2010 Asian Network for Scientific Information.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955644960&partnerID=40&md5=6a93a9492cb7168701f4b95d9546f210
http://ir.swu.ac.th/jspui/handle/123456789/14682
ISSN: 18117775
Appears in Collections:SCOPUS 1983-2021

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