Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14524
Title: Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: A pilot study
Authors: Udompataikul M.
Srisatwaja W.
Keywords: ceramide
hydrocortisone
lanolin alcohol
licochalcone A
linoleic acid
adolescent
article
atopic dermatitis
child
clinical article
drug efficacy
dry skin
edema
erythema
female
human
lichenoid eruption
lotion
male
preschool child
priority journal
pruritus
randomized controlled trial
recurrence risk
school child
scoring of atopic dermatitis index
scoring system
skin excoriation
statistical significance
survival
Administration, Cutaneous
Adolescent
Analysis of Variance
Anti-Inflammatory Agents
Chalcones
Child
Child, Preschool
Dermatitis, Atopic
Emollients
Female
Humans
Hydrocortisone
Infant
Kaplan-Meier Estimate
Male
Patient Satisfaction
Pilot Projects
Recurrence
Severity of Illness Index
Single-Blind Method
Treatment Outcome
Issue Date: 2011
Abstract: Background Although moisturizer usage has been considered a mainstay of treatment for atopic dermatitis (AD) patients, few clinical studies have been investigated. Recently, moisturizers containing non-steroidal anti-inflammatory agents, such as licochalcone A (LA) and vitamin B12 are of emerging interest. Objective To compare the effectiveness of moisturizer containing LA with hydrocortisone (HC) lotion in treatment of childhood AD. Methods The randomized, controlled, investigator-blinded 6-week study was conducted. Patients were administered with twice-daily application of LA lotion on one side of the body and HC lotion on the opposite side. The clinical outcome was assessed by the scoring of atopic dermatitis (SCORAD) index. The relapse rate was comparatively analysed by survival analysis. Results From 30 patients enrolled, 26 patients completed the protocol. The mean age of the children was 5.8 years. The average baseline SCORAD score is about 28 on both sides. The response rates of both agents were equal to 73.33%. There is no statistical significant group difference in reduction of SCORAD score. Although we observed more rapid resolution of oedema and erythema in areas treated with HC lotion, both agents exhibited no significant difference. The relapse rate of HC group was higher than in LA group; however, there was no significant difference. No side-effect was observed from both agents. Conclusion The effectiveness of LA lotion is equal to that of HC lotion. It was suggested that moisturizer containing LA could be used both for treatment of acute and maintenance phase in mild-to-moderate childhood AD. © 2010 European Academy of Dermatology and Venereology and Venereology.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955928097&doi=10.1111%2fj.1468-3083.2010.03845.x&partnerID=40&md5=b1f628db4a1b2e77b435fc413babc2fa
http://ir.swu.ac.th/jspui/handle/123456789/14524
ISSN: 9269959
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.