Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14508
Title: Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels
Authors: Asasutjarit R.
Thanasanchokpibull S.
Fuongfuchat A.
Veeranondha S.
Keywords: benzalkonium chloride
carbopol 940
diclofenac
poloxamer
animal cell
animal experiment
aqueous humor
article
autoclave
controlled study
drug absorption
drug bioavailability
drug formulation
eye irritation
female
flow kinetics
gel
in vivo study
male
nonhuman
pH
priority journal
rabbit
shear flow
transition temperature
Acrylic Resins
Administration, Ophthalmic
Animals
Anti-Inflammatory Agents, Non-Steroidal
Aqueous Humor
Diclofenac
Drug Administration Routes
Drug Compounding
Drug Delivery Systems
Excipients
Eye
Gels
Hot Temperature
Male
Ophthalmic Solutions
Phase Transition
Physicochemical Phenomena
Poloxamer
Rabbits
Sterilization
Transition Temperature
Issue Date: 2011
Abstract: This work was conducted to optimize and evaluate Pluronic F127-based thermoresponsive diclofenac sodium ophthalmic in situ gels (DS in situ gel). They were prepared by cold method and investigated their physicochemical properties i.e., pH, flow ability, sol-gel transition temperature, gelling capacity and rheological properties. An optimized formulation was selected and investigated its physicochemical properties before and after autoclaving, eye irritation potency in SIRC cells and rabbits. In vivo ophthalmic absorption was performed in rabbits. It was found that physicochemical properties of DS in situ gels were affected by formulation compositions. Increment of Pluronic F127 content decreased sol-gel transition temperature of the products while increase in Pluronic F68 concentration tended to increase sol-gel transition temperature. In this study, Carbopol 940 did not affect sol-gel transition temperature but it affected transparency, pH, and gelling capacity of the products. The optimized formulation exhibited sol-gel transition at 32.6 ± 1.1°C with pseudoplastic flow behavior. It was lost diclofenac sodium content during autoclaving. However, it was accepted as safe for ophthalmic use and could increase diclofenac sodium bioavailability in aqueous humor significantly. In conclusion, the optimized DS in situ gel had potential for using as an alternative to the conventional diclofenac sodium eye drop. However, autoclaving was not a suitable sterilization method for this product. © 2011 Elsevier B.V. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955964137&doi=10.1016%2fj.ijpharm.2011.03.054&partnerID=40&md5=e6796a020ba5dd296f3ed09e332ccf9f
http://ir.swu.ac.th/jspui/handle/123456789/14508
ISSN: 3785173
Appears in Collections:SCOPUS 1983-2021

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