Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14435
Title: Investigation on biological activities of anthranilic acid sulfonamide analogs
Authors: Doungsoongnuen S.
Worachartcheewan A.
Pingaew R.
Suksrichavalit T.
Prachayasittikul S.
Ruchirawat S.
Prachayasittikul V.
Keywords: 2 (4' chlorophenylsulfonamido)benzoic acid
2 (4' methoxyphenylsulfonamido)benzoic acid
2 (4' methylphenylsulfonamido)benzoic acid
2 (4' nitrophenylsulfonamido)benzoic acid
ampicillin
antifungal agent
antiinfective agent
antioxidant
benzenesulfonamide derivative
cytotoxic agent
doxorubicin
etoposide
unclassified drug
antifungal activity
antioxidant activity
article
Candida albicans
concentration response
controlled study
cytotoxicity
drug mechanism
drug structure
human
human cell
minimum inhibitory concentration
nonhuman
structure activity relation
Issue Date: 2011
Abstract: In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50% inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO2) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855815989&partnerID=40&md5=9815e2911bcb9dea89cdcaaca0c01b43
http://ir.swu.ac.th/jspui/handle/123456789/14435
ISSN: 16112156
Appears in Collections:SCOPUS 1983-2021

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