Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14387
Title: OPCML gene as a schizophrenia susceptibility locus in Thai population.
Authors: Panichareon B.
Nakayama K.
Thurakitwannakarn W.
Iwamoto S.
Sukhumsirichart W.
Keywords: cell adhesion molecule
glycosylphosphatidylinositol anchored protein
OPCML protein, human
adult
article
comparative study
DNA denaturation
ethnic group
ethnology
female
gene frequency
genetic predisposition
genetics
genotype
human
intron
male
middle aged
physiology
polymerase chain reaction
risk
schizophrenia
single nucleotide polymorphism
Thailand
Adult
Cell Adhesion Molecules
Ethnic Groups
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
GPI-Linked Proteins
Humans
Introns
Male
Middle Aged
Nucleic Acid Denaturation
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Risk
Schizophrenia
Thailand
Issue Date: 2012
Abstract: Opioid-binding protein/cell adhesion molecule (OPCML) gene has been recently identified as a susceptibility gene for schizophrenia in Europeans. This study aims to investigate the association between single nucleotide polymorphisms (SNPs) in the OPCML gene and risk of schizophrenia in a Thai population. DNA samples of 115 schizophrenia patients and 173 normal controls were genotyped using high-resolution melting analysis and analyzed by chi-square test of SPSS software. We observed a strong association between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population [P = 0.00036; odds ratio for the minor A allele, 2.11(1.57-2.84)]. The previously discovered SNP associated with schizophrenia in Europeans, rs3016384, also showed significant association with schizophrenia in the Thai population [P = 0.01; odds ratio of the minor T allele, 0.59 (0.44-0.79)]. Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14387
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866166274&doi=10.1007%2fs12031-011-9595-2&partnerID=40&md5=10364b41dc16fed9eb8e0066ccc53f96
ISSN: 15591166
Appears in Collections:Scopus 1983-2021

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