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Title: Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: A pilot study
Authors: Udompataikul M.
Limpa-o-vart D.
Keywords: dexpanthenol
water oil cream
absence of side effects
age distribution
atopic dermatitis
clinical article
controlled study
disease severity
drug efficacy
drug formulation
lichenoid eruption
pilot study
preschool child
randomized controlled trial
school child
scoring system
single blind procedure
skin absorption
Student t test
treatment duration
treatment response
Administration, Cutaneous
Case-Control Studies
Child, Preschool
Dermatitis, Atopic
Dermatologic Agents
Pantothenic Acid
Pilot Projects
Single-Blind Method
Time Factors
Treatment Outcome
Issue Date: 2012
Abstract: Background: Atopic dermatitis (AD) is a common chronic relapsing disease particularly affecting children. The emollient used for protection of skin barrier function is the standard treatment for patients with AD. Currently, there is a growing interest in the use of nonsteroidal anti-inflammatory agents such as dexpanthenol (vitamin B5) as an alternative treatment. Objective: To compare the effectiveness of 5% dexpanthenol (DT) ointment with 1% hydrocortisone (HC) ointment in childhood AD therapy. Method: Patients were treated topically with 5% DT ointment on the right side of the body and 1% HC ointment on the other side twice daily for 4 weeks. The clinical responses were evaluated by SCORAD (Scoring Atopic Dermatitis index) with statistical analysis using paired t-test. Result: Of the 30 children enrolled, 26 completed the protocol; mean age was 7.19 years. The average baseline SCORAD score of the DT-treated side and the HC-treated side was 30.95 and 30.54, respectively. There was no statistically significant difference in SCORAD score reduction between the 2 agents. The edematous score of the HC-treated side exhibited faster resolution than that of the DT-treated side, with a statistically significant difference at week 1 and without a statistically significant difference at weeks 2 to 4. The lichenification response rate of HC treatment was more rapid than that of DT treatment; however, there was no statistical group difference. No adverse events were observed with either agent. Conclusion: The effectiveness of 5% DT ointment is equal to that of 1% HC ointment. DT ointment may be used as alternative treatment in mild to moderate childhood AD therapy. Copyright © 2012 Journal of Drugs in Dermatology.
ISSN: 15459616
Appears in Collections:Scopus 1983-2021

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