Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14257
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dc.contributor.authorNittayananta W.
dc.contributor.authorMitarnun W.
dc.contributor.authorTalungchit S.
dc.contributor.authorSriplung H.
dc.date.accessioned2021-04-05T03:33:51Z-
dc.date.available2021-04-05T03:33:51Z-
dc.date.issued2012
dc.identifier.issn1354523X
dc.identifier.other2-s2.0-84866864081
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84866864081&doi=10.1111%2fj.1601-0825.2012.01947.x&partnerID=40&md5=a53094816c764fdb295eab6ae03d3a33
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/14257-
dc.description.abstractObjectives: The objectives of this study were to determine (i) the expression of oral cytokeratins (CKs) among human immunodeficiency virus (HIV)-infected subjects compared with non-HIV controls, (ii) the oral CK expression in the subjects with highly active antiretroviral therapy (HAART) compared with those without HAART, and (iii) factors associated with the expression of oral CKs. Materials and methods: Oral tissues from buccal mucosa were obtained by punched biopsy in HIV-infected subjects with and without HAART, and non-HIV individuals. The samples were processed for immunohistochemical studies of CK1, CK13, CK14, CK16, and involucrin. The staining intensity was scored and recorded. Logistic regression analysis and multi-way ANOVA test were performed. Results: The expression of CK13, CK14, and CK16 was found to be significantly different between HIV-infected subjects and non-HIV individuals (P<0.05). The expression of those CKs was also significantly different between those who were and were not on HAART (P<0.05). No significant difference between the groups was observed regarding CK1 and involucrin. Conclusions: Oral epithelial cell differentiation as marked by the CK expression is affected by HIV infection and use of HAART. CKs may be the useful biomarkers to identify HIV-infected subjects who are at risk of malignant transformation of the oral mucosa because of HIV infection and HAART. © 2012 John Wiley & Sons A/S.
dc.subjectcytokeratin 1
dc.subjectcytokeratin 13
dc.subjectcytokeratin 14
dc.subjectcytokeratin 16
dc.subjectinvolucrin
dc.subjectadult
dc.subjectarticle
dc.subjectcheek mucosa
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdifferentiation
dc.subjectepithelium cell
dc.subjectfemale
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmouth
dc.subjectmouth mucosa
dc.subjectpredictive value
dc.subjectpriority journal
dc.subjectprotein analysis
dc.subjectprotein expression
dc.subjectpunch biopsy
dc.subject3,3'-Diaminobenzidine
dc.subjectAdult
dc.subjectAlcohol Drinking
dc.subjectAntiretroviral Therapy, Highly Active
dc.subjectBiopsy, Needle
dc.subjectCD4 Lymphocyte Count
dc.subjectChromogenic Compounds
dc.subjectCross-Sectional Studies
dc.subjectEpithelial Cells
dc.subjectFemale
dc.subjectHIV
dc.subjectHIV Infections
dc.subjectHIV Seropositivity
dc.subjectHumans
dc.subjectKeratin-1
dc.subjectKeratin-13
dc.subjectKeratin-14
dc.subjectKeratin-16
dc.subjectKeratins
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Mucosa
dc.subjectProtein Precursors
dc.subjectSmoking
dc.subjectViral Load
dc.subjectYoung Adult
dc.titleChanges in oral cytokeratin expression in HIV-infected subjects with long-term use of HAART
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationOral Diseases. Vol 18, No.8 (2012), p.793-801
dc.identifier.doi10.1111/j.1601-0825.2012.01947.x
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