Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14256
Title: Antioxidant, cytotoxicity, and QSAR study of 1-Adamantylthio derivatives of 3-picoline and phenylpyridines
Authors: Worachartcheewan A.
Prachayasittikul S.
Pingaew R.
Nantasenamat C.
Tantimongcolwat T.
Prachayasittikul S.R.
Prachayasittikul V.
Keywords: 1,1 diphenyl 2 picrylhydrazyl
picoline derivative
pyridine derivative
superoxide
antioxidant activity
article
biological activity
cytotoxicity
dipole
drug structure
electrophilicity
energy
molecular weight
proton nuclear magnetic resonance
quantitative structure activity relation
quantum chemistry
Issue Date: 2012
Abstract: A series of isomeric α-And β-(1-Adamantylthio) pyridines were previously documented to possess interesting antimicrobial and antimalarial activities. In this study, the antioxidant and cytotoxic potentials of 1-Adamantylthio-3-methyl and 2-,3-,4-phenylpyridines (1-10) were investigated. The tested compounds were shown to exhibit interesting superoxide (SOD)-And free radical (DPPH)-scavenging activities as well as cytotoxic activities. Particularly, β-(1-Adamantylthio)-4-phenylpyridine (8) was shown to be the most potent antioxidant and cytotoxic compound. QSAR studies revealed that dipole moment (l) and electrophilic index (xi) were the most important descriptors accounting for the observed SOD activities. Compounds with high l and xi values were observed to display high SOD activity. Inversely, compounds with the lowest atomic polarizability (MATS4p) exhibited the highest DPPH activity. Other quantum chemical descriptors such as atomic masses (GATS4m), xi, and LUMO energy were also well correlated with cytotoxicity. The findings demonstrated that thiopyridine 8 is a potential lead compound that should be further investigated in drug discovery efforts. The QSAR results offer good prospect for the rational design of novel compounds with robust bioactivities. © Springer Science+Business Media, LLC 2011.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878504136&doi=10.1007%2fs00044-011-9903-y&partnerID=40&md5=afe1c8b495e00631c728cf760dbb1887
http://ir.swu.ac.th/jspui/handle/123456789/14256
ISSN: 10542523
Appears in Collections:SCOPUS 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.