Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14049
Title: Antimicrobial activity of 8-hydroxyquinoline and transition metal complexes
Authors: Srisung S.
Suksrichavalit T.
Prachayasittikul S.
Ruchirawat S.
Prachayasittikul V.
Keywords: 5 nitrouracil
8 quinolinol
8 quinolinol copper 5 iodouracil
8 quinolinol copper 5 nitrouracil
8 quinolinol derivative
8 quinolinol manganese 5 iodouracil
8 quinolinol manganese 5 nitrouracil
8 quinolinol nickel 5 iodouracil
8 quinolinol nickel 5 nitrouracil
ampicillin
antiinfective agent
copper
heterocyclic compound
iodouracil
manganese
natural product
nickel
nitrogen oxide
transition element
unclassified drug
uracil
uracil derivative
antimicrobial activity
article
bacterial strain
Candida albicans
complex formation
controlled study
drug design
drug potency
drug structure
drug synthesis
Enterococcus faecalis
Gram negative bacterium
Gram positive bacterium
growth inhibition
minimum inhibitory concentration
nonhuman
Staphylococcus aureus
Issue Date: 2013
Abstract: Heterocyclic compounds like 8-hydroxyquinoline (8HQ) and derivatives have been found in natural products and therapeutics. Herein 8HQ and metal complexes of 8HQ-5-substituted (X) uracils, X = I, N02 (1-6) were investigated for their antimicrobial potency. The complexes 1 -6 exhibited growth inhibition against many strains of gram-positive and gram-negative bacteria with minimum inhibitory concentrations (MICs) of 575.71-718.76 uM. The investigated compound 8HQ was shown to be a very strong antimicrobial agent with the MIC of 27.58 uM that comparable to ampicillin (MIC 26.93 uM), the reference drug. The activity of 8HQ mostly was observed for resistant pathogens, gram- positive bacteria e.g. Staphylococcus aureus, Enterococcus faecalis and diploid fungus, Candida albicans. The findings reveal 8HQ as the very potent antimicrobial agent and a series of 8HQ transition metal complexes as novel antimicrobials as well as the applications of 8HQ for the design and synthesis of new and potential therapeutic lead compounds. © 2013 Asian Network for Scientific Information.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878828933&doi=10.3923%2fijp.2013.170.175&partnerID=40&md5=80a8a2ebf24a7c99612afad3630a221b
http://ir.swu.ac.th/jspui/handle/123456789/14049
ISSN: 18117775
Appears in Collections:SCOPUS 1983-2021

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