Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/13991
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dc.contributor.authorLertdumrongluk P.
dc.contributor.authorLau W.L.
dc.contributor.authorPark J.
dc.contributor.authorRhee C.M.
dc.contributor.authorKovesdy C.P.
dc.contributor.authorKalantar-Zadeh K.
dc.date.accessioned2021-04-05T03:32:48Z-
dc.date.available2021-04-05T03:32:48Z-
dc.date.issued2013
dc.identifier.issn9310509
dc.identifier.other2-s2.0-84884958861
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84884958861&doi=10.1093%2fndt%2fgft290&partnerID=40&md5=d17304c71b36e57391f89d332857f9b8
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/13991-
dc.description.abstractBackgroundAbnormalities in serum alkaline phosphatase (ALP) and intact parathyroid hormone (PTH) concentrations, as biochemical markers of bone turnover in dialysis patients, correlate with increased mortality in maintenance hemodialysis (MHD) patients. Changes in bone turnover rate vary with age. The mortality predictability of serum ALP and PTH levels in MHD patients may be different across ages.MethodsWe examined differences across four age groups (18 to <45, 45 to <65, 65 to <75 and ≥75 years) in the mortality predictability of serum ALP and PTH in 102 149 MHD patients using Cox models.ResultsHigher serum ALP levels were associated with higher mortality across all ages; however, the ALP-mortality association was much stronger in young patients (<45 years) compared with older patients. The association between higher serum PTH levels and mortality was stronger in older patients compared with the younger groups. Serum PTH levels were incrementally associated with mortality only in middle-aged and elderly patients (≥45 years). Compared with patients with serum PTH 150 to <300pg/mL, the death risks were higher in patients with serum PTH 300 to <600pg/mL [HRs (95% CI): 1.05 (1.01-1.10), 1.15 (1.10-1.21) and 1.25 (1.19-1.31) for patients 45 to <65, 65 to <75 and ≥75 years, respectively], and ≥600pg/mL [HRs(95% CI): 1.07 (1.01-1.14), 1.31(1.21-1.42) and 1.45(1.33-1.59) for age categories 45 to <65, 65 to <75 and ≥75 years, respectively]. However, no significant association between higher serum PTH levels and mortality was observed in patients <45 years.ConclusionsThere are important differences in mortality-predictability of serum ALP and PTH in older MHD patients compared with their younger counterparts. The effect of age needs to be considered when interpreting the prognostic implications of serum ALP and PTH levels. © 2013 The Author. All rights reserved.
dc.subjectalbumin
dc.subjectalkaline phosphatase
dc.subjectcreatinine
dc.subjectparathyroid hormone
dc.subjectadult
dc.subjectage distribution
dc.subjectaged
dc.subjectalbumin blood level
dc.subjectalkaline phosphatase blood level
dc.subjectarticle
dc.subjectbody mass
dc.subjectbone turnover
dc.subjectcardiovascular mortality
dc.subjectcohort analysis
dc.subjectcreatinine blood level
dc.subjectdisease association
dc.subjectfemale
dc.subjectgroups by age
dc.subjecthemodialysis patient
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectparathyroid hormone blood level
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectage
dc.subjectalkaline phosphatase
dc.subjectbone turnover markers
dc.subjecthemodialysis
dc.subjectparathyroid hormone
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlkaline Phosphatase
dc.subjectBiological Markers
dc.subjectBone and Bones
dc.subjectBone Remodeling
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGlomerular Filtration Rate
dc.subjectHumans
dc.subjectKidney Diseases
dc.subjectKidney Function Tests
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectParathyroid Hormone
dc.subjectPrognosis
dc.subjectRenal Dialysis
dc.subjectSurvival Rate
dc.subjectYoung Adult
dc.titleImpact of age on survival predictability of bone turnover markers in hemodialysis patients
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationNephrology Dialysis Transplantation. Vol 28, No.10 (2013), p.2535-2545
dc.identifier.doi10.1093/ndt/gft290
Appears in Collections:Scopus 1983-2021

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