Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/13971
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLertdumrongluk P.
dc.contributor.authorRhee C.M.
dc.contributor.authorPark J.
dc.contributor.authorLau W.L.
dc.contributor.authorMoradi H.
dc.contributor.authorJing J.
dc.contributor.authorMolnar M.Z.
dc.contributor.authorBrunelli S.M.
dc.contributor.authorNissenson A.R.
dc.contributor.authorKovesdy C.P.
dc.contributor.authorKalantar-Zadeh K.
dc.date.accessioned2021-04-05T03:32:46Z-
dc.date.available2021-04-05T03:32:46Z-
dc.date.issued2013
dc.identifier.issn10512276
dc.identifier.other2-s2.0-84886245085
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84886245085&doi=10.1053%2fj.jrn.2013.01.018&partnerID=40&md5=c7c3853214f225bb2a1a0e150f5b00bb
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/13971-
dc.description.abstractObjective: Hypo- and hyperphosphatemia have each been associated with increased mortality in maintenance hemodialysis (MHD) patients. There has not been previous evaluation of a differential relationship between serum phosphorus level and death risk across varying age groups in MHD patients. Design and Settings: In a 6-year cohort of 107,817 MHD patients treated in a large dialysis organization, we examined the association between serum phosphorus levels with all-cause and cardiovascular mortality within 5 age categories (15 to <45, 45 to <65, 65 to <70, 70 to <75, and ≥75 years old) using Cox proportional hazards models adjusted for case-mix covariates and malnutrition inflammation complex syndrome (MICS) surrogates. Main Outcome Measure: All-cause and cardiovascular mortality. Results: The overall mean age of the cohort was 60 ± 16 years, among whom there were 45% women, 35% Blacks, and 58% diabetics. The time-averaged serum phosphorus level (mean±SD) within each age category was 6.26 ± 1.4, 5.65 ± 1.2, 5.26 ± 1.1, 5.11 ± 1.0, and 4.88 ± 1.0 mg/dL, respectively (P for trend <.001). Hyperphosphatemia (>5.5 mg/dL) was consistently associated with increased all-cause and cardiovascular mortality risks across all age categories, including after adjustment for case-mix and MICS-related covariates. In fully adjusted models, a low serum phosphorus level (<3.5 mg/dL) was associated with increased all-cause mortality only in elderly MHD patients ≥65 years old (hazard ratio [95% confidence interval]: 1.21 [1.07-1.37], 1.13 [1.02-1.25], and 1.28 [1.2-1.37] for patients 65 to <70, 70 to <75, and ≥75 years old, respectively), but not in younger patients (<65 years old). A similar differential cardiovascular mortality risk for low serum phosphorus levels between old and young age groups was observed. Conclusions: The association between hyperphosphatemia and mortality is similar across all age groups of MHD patients, whereas hypophosphatemia is associated with increased mortality only in elderly MHD patients. Preventing very low serum phosphorus levels in elderly dialysis patients may be associated with better outcomes, which needs to be examined in future studies. © 2013 National Kidney Foundation, Inc.
dc.subjectphosphorus
dc.subjectadolescent
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectarticle
dc.subjectblood
dc.subjectcardiovascular disease
dc.subjectcohort analysis
dc.subjectfemale
dc.subjecthuman
dc.subjecthyperphosphatemia
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectrenal replacement therapy
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAged
dc.subjectCardiovascular Diseases
dc.subjectCohort Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectHyperphosphatemia
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPhosphorus
dc.subjectRenal Dialysis
dc.titleAssociation of serum phosphorus concentration with mortality in elderly and nonelderly hemodialysis patients
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Renal Nutrition. Vol 23, No.6 (2013), p.411-421
dc.identifier.doi10.1053/j.jrn.2013.01.018
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.