Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/13907
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dc.contributor.authorNittayananta W.
dc.contributor.authorAmornthatree K.
dc.contributor.authorKemapunmanus M.
dc.contributor.authorTalungchit S.
dc.contributor.authorSriplung H.
dc.date.accessioned2021-04-05T03:32:38Z-
dc.date.available2021-04-05T03:32:38Z-
dc.date.issued2014
dc.identifier.issn1354523X
dc.identifier.other2-s2.0-84896076057
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84896076057&doi=10.1111%2fodi.12135&partnerID=40&md5=997a39837c12dd6cde70504d5ae30754
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/13907-
dc.description.abstractObjectives: The objectives of this study were to determine (i) the expression of oral pro-inflammatory cytokines in HIV-infected subjects compared with non-HIV individuals, (ii) the cytokine expression in the subjects with antiretroviral therapy (ART) compared with those without ART, and (iii) factors associated with the expression of the cytokines. Materials and methods: Oral examination was performed and saliva samples were collected and analyzed for the expression of pro-inflammatory cytokines using ELISA. Logistic regression analysis was performed to determine the association between HIV/ART status and the cytokine expression. Results: One hundred and fifty-seven HIV-infected subjects with and without ART, and 50 non-HIV individuals were enrolled. TNF-α and IL-6 in saliva were significantly decreased, while IL-8 was significantly increased in HIV infection (P < 0.05). Changes in the expression of IL-8 were also observed between HIV-infected subjects who were and were not on ART (P < 0.05). Duration of HIV infection and smoking was significantly associated with the expression of pro-inflammatory cytokines in saliva (P < 0.05). Conclusion: Oral innate immunity is affected by HIV infection and use of ART. IL-8 may be the useful biomarker to identify subjects at risk of infection and malignant transformation due to HIV infection and long-term use of ART. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.subjectinterleukin 6
dc.subjectinterleukin 8
dc.subjectnonnucleoside reverse transcriptase inhibitor
dc.subjectproteinase inhibitor
dc.subjectRNA directed DNA polymerase inhibitor
dc.subjecttumor necrosis factor alpha
dc.subjectanti human immunodeficiency virus agent
dc.subjectcytokine
dc.subjectadult
dc.subjectantiviral therapy
dc.subjectarticle
dc.subjectCD4 lymphocyte count
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdisease association
dc.subjectdisease duration
dc.subjectdrinking behavior
dc.subjectfemale
dc.subjectflow rate
dc.subjecthairy leukoplakia
dc.subjecthealth status
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infected patient
dc.subjectHuman immunodeficiency virus infection
dc.subjecthyperpigmentation
dc.subjectlong term care
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmouth lesion
dc.subjectoral bleeding
dc.subjectperiodontal pocket
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectsaliva analysis
dc.subjectsmoking
dc.subjectstomatitis
dc.subjectthrush
dc.subjectvirus load
dc.subjectbiosynthesis
dc.subjectchemistry
dc.subjectHIV Infections
dc.subjectmetabolism
dc.subjectsaliva
dc.subjecttime factor
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAnti-HIV Agents
dc.subjectCross-Sectional Studies
dc.subjectCytokines
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSaliva
dc.subjectTime Factors
dc.subjectYoung Adult
dc.titleExpression of oral cytokines in HIV-infected subjects with long-term use of antiretroviral therapy
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationOral Diseases. Vol 20, No.3 (2014), p.e57-e64
dc.identifier.doi10.1111/odi.12135
Appears in Collections:Scopus 1983-2021

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