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Title: The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study
Authors: Treesirichod A.
Chaithirayanon S.
Wongjitrat N.
Wattanapan P.
Keywords: adapalene
acanthosis nigricans
application site burning
application site dryness
application site erythema
application site irritation
application site pruritus
body mass
childhood disease
clinical article
clinical evaluation
comparative effectiveness
controlled clinical trial
controlled study
disease predisposition
drug efficacy
drug tolerability
drug use
dry skin
pilot study
rating scale
skin abrasion
skin burning sensation
skin color
skin irritation
skin pruritus
topical treatment
treatment duration
weight change
Issue Date: 2015
Abstract: Aims: To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel. Subjects and Methods: A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation (IGE) scale and the parent's global evaluation (PGE) scale were used to assess the efficacy of the patients' treatment at the end of the 4th week. Results: The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen. Conclusions: The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation. © 2015 Indian Journal of Dermatology.
ISSN: 195154
Appears in Collections:Scopus 1983-2021

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